MBCProject_5774_T2_RNA
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- NOTCH_SIGNALING+0.370
- ADIPOGENESIS+0.290
- UV_RESPONSE_DN+0.280
- WNT_BETA_CATENIN_SIGNALING+0.230
- TGF_BETA_SIGNALING+0.200
- MYOGENESIS+0.170
- HEME_METABOLISM+0.150
- FATTY_ACID_METABOLISM+0.140
- HEDGEHOG_SIGNALING+0.140
- BILE_ACID_METABOLISM+0.040
Top 10 suppressed
- MTORC1_SIGNALING-0.470
- INTERFERON_ALPHA_RESPONSE-0.450
- ALLOGRAFT_REJECTION-0.440
- MYC_TARGETS_V1-0.420
- E2F_TARGETS-0.410
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- INTERFERON_GAMMA_RESPONSE-0.380
- ANGIOGENESIS-0.360
- G2M_CHECKPOINT-0.320
- UNFOLDED_PROTEIN_RESPONSE-0.310
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2208935 | — | — | 0.867 |
| 2 | BSR_06_0173_A4_S51 | — | A | 0.859 |
| 3 | SRR6013544 | — | cohortA1 | 0.854 |
| 4 | TCGA-55-8097-01A-11R-2241-07 | — | cohortA1 | 0.841 |
| 5 | TCGA-55-8087-01A-11R-2241-07 | — | cohortA1 | 0.827 |
| 6 | TCGA-73-7498-01A-12R-2187-07 | — | cohortA2 | 0.825 |
| 7 | s0122235 | — | — | 0.819 |
| 8 | BSR_10_0261_B3_S85 | — | A | 0.819 |
| 9 | s0112264 | — | — | 0.818 |
| 10 | BS_264RCK7G | DNET | — | 0.817 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| NOTCH_SIGNALING | 0.370 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.290 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.280 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.230 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.200 | Inavolisib | — uncovered |
| MYOGENESIS | 0.170 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.150 | Temsirolimus | — uncovered |
| FATTY_ACID_METABOLISM | 0.140 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.140 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.040 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.020 | Temsirolimus | — uncovered |