MNG453
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.351
- PROTEIN_SECRETION+0.280
- OXIDATIVE_PHOSPHORYLATION+0.220
- SPERMATOGENESIS+0.158
- XENOBIOTIC_METABOLISM+0.147
- FATTY_ACID_METABOLISM+0.052
- MYC_TARGETS_V1+0.039
- MTORC1_SIGNALING+0.034
- BILE_ACID_METABOLISM-0.006
- ANGIOGENESIS-0.022
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.542
- INTERFERON_GAMMA_RESPONSE-0.462
- INTERFERON_ALPHA_RESPONSE-0.453
- ALLOGRAFT_REJECTION-0.450
- IL6_JAK_STAT3_SIGNALING-0.445
- INFLAMMATORY_RESPONSE-0.421
- E2F_TARGETS-0.409
- MYC_TARGETS_V2-0.406
- MITOTIC_SPINDLE-0.400
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.387
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-2960 | Med | Medulloblastoma | 0.892 |
| 2 | SRR35579848 | — | B | 0.883 |
| 3 | TCGA-37-4129-01A-01R-1100-07 | — | cohortSC | 0.880 |
| 4 | TCGA-D8-A1XV-01A-11R-A14M-07 | — | B | 0.865 |
| 5 | SRR25617889 | — | B | 0.858 |
| 6 | SAMN03290937 | — | — | 0.856 |
| 7 | TCGA-E9-A245-01A-22R-A16F-07 | — | B | 0.855 |
| 8 | SRR10899984 | — | — | 0.848 |
| 9 | SRR1464327 | GTEX | — | 0.844 |
| 10 | SRR1072504 | GTEX | — | 0.844 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.351 | Cobimetinib | — uncovered |
| PROTEIN_SECRETION | 0.280 | Remibrutinib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.220 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.158 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.147 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.052 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.039 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.034 | Inavolisib | — uncovered |