SRR1385036
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.138
- MYC_TARGETS_V2+0.100
- UNFOLDED_PROTEIN_RESPONSE+0.050
- SPERMATOGENESIS+0.026
- KRAS_SIGNALING_DN+0.023
- MITOTIC_SPINDLE-0.005
- OXIDATIVE_PHOSPHORYLATION-0.008
- MYC_TARGETS_V1-0.051
- PEROXISOME-0.071
- HEME_METABOLISM-0.073
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.570
- ANGIOGENESIS-0.558
- TNFA_SIGNALING_VIA_NFKB-0.552
- INTERFERON_GAMMA_RESPONSE-0.535
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.521
- INFLAMMATORY_RESPONSE-0.487
- APOPTOSIS-0.464
- IL6_JAK_STAT3_SIGNALING-0.458
- TGF_BETA_SIGNALING-0.458
- ALLOGRAFT_REJECTION-0.448
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1456531 | GTEX | — | 0.984 |
| 2 | SRR1441224 | GTEX | — | 0.981 |
| 3 | SRR1477385 | GTEX | — | 0.979 |
| 4 | SRR1069188 | GTEX | — | 0.979 |
| 5 | SRR1357413 | GTEX | — | 0.979 |
| 6 | SRR1419675 | GTEX | — | 0.979 |
| 7 | SRR807657 | GTEX | — | 0.978 |
| 8 | SRR1464305 | GTEX | — | 0.977 |
| 9 | SRR1359367 | GTEX | — | 0.977 |
| 10 | SRR1352415 | GTEX | — | 0.976 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.138 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.100 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.050 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.026 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.023 | Remibrutinib | — uncovered |