SRR1465356
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.246
- KRAS_SIGNALING_DN+0.241
- OXIDATIVE_PHOSPHORYLATION+0.215
- SPERMATOGENESIS+0.188
- MYOGENESIS+0.087
- ESTROGEN_RESPONSE_EARLY+0.020
- FATTY_ACID_METABOLISM-0.005
- PEROXISOME-0.025
- ADIPOGENESIS-0.063
- HEME_METABOLISM-0.063
Top 10 suppressed
- ANGIOGENESIS-0.533
- ALLOGRAFT_REJECTION-0.498
- INFLAMMATORY_RESPONSE-0.495
- E2F_TARGETS-0.474
- IL6_JAK_STAT3_SIGNALING-0.462
- G2M_CHECKPOINT-0.456
- INTERFERON_ALPHA_RESPONSE-0.452
- INTERFERON_GAMMA_RESPONSE-0.451
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.415
- MYC_TARGETS_V1-0.411
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1477634 | GTEX | — | 0.979 |
| 2 | SRR1474065 | GTEX | — | 0.971 |
| 3 | SRR1322555 | GTEX | — | 0.971 |
| 4 | SRR1359388 | GTEX | — | 0.969 |
| 5 | SRR1397094 | GTEX | — | 0.964 |
| 6 | SRR1335651 | GTEX | — | 0.960 |
| 7 | SRR1477197 | GTEX | — | 0.957 |
| 8 | SRR1339218 | GTEX | — | 0.950 |
| 9 | SRR1478077 | GTEX | — | 0.949 |
| 10 | SRR1370619 | GTEX | — | 0.949 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.246 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.241 | Remibrutinib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.215 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.188 | Inavolisib | — uncovered |
| MYOGENESIS | 0.087 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.020 | Inavolisib | — uncovered |