MNG1156
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.402
- KRAS_SIGNALING_DN+0.326
- SPERMATOGENESIS+0.223
- MYOGENESIS+0.128
- INTERFERON_GAMMA_RESPONSE+0.071
- COAGULATION+0.070
- INTERFERON_ALPHA_RESPONSE+0.047
- ESTROGEN_RESPONSE_LATE+0.010
- APICAL_JUNCTION-0.018
- ESTROGEN_RESPONSE_EARLY-0.047
Top 10 suppressed
- MYC_TARGETS_V2-0.631
- OXIDATIVE_PHOSPHORYLATION-0.583
- MYC_TARGETS_V1-0.560
- UNFOLDED_PROTEIN_RESPONSE-0.542
- WNT_BETA_CATENIN_SIGNALING-0.541
- NOTCH_SIGNALING-0.512
- DNA_REPAIR-0.479
- PROTEIN_SECRETION-0.446
- TGF_BETA_SIGNALING-0.421
- ADIPOGENESIS-0.417
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG597 | — | — | 0.951 |
| 2 | MNG436 | — | — | 0.939 |
| 3 | SRR1366141 | GTEX | — | 0.934 |
| 4 | MNG599 | — | — | 0.931 |
| 5 | SRR12696761 | — | — | 0.930 |
| 6 | MNG1131 | — | — | 0.927 |
| 7 | 08e3d239-3d8a-4eee-9e08-ac2bcb3f2619 | — | — | 0.926 |
| 8 | MNG1259 | — | — | 0.926 |
| 9 | TCGA-CF-A3MF-01A-12R-A21D-07 | — | — | 0.921 |
| 10 | MNG598 | — | — | 0.921 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.402 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.326 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.223 | Inavolisib | — uncovered |
| MYOGENESIS | 0.128 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.071 | Idelalisib | — uncovered |
| COAGULATION | 0.070 | Binimetinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.047 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.010 | Idelalisib | — uncovered |