SRR650196
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.380
- OXIDATIVE_PHOSPHORYLATION+0.270
- NOTCH_SIGNALING+0.150
- PANCREAS_BETA_CELLS+0.140
- HEME_METABOLISM+0.100
- PEROXISOME+0.100
- WNT_BETA_CATENIN_SIGNALING+0.090
- ESTROGEN_RESPONSE_EARLY+0.080
- P53_PATHWAY+0.060
- ESTROGEN_RESPONSE_LATE+0.040
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.550
- TNFA_SIGNALING_VIA_NFKB-0.540
- ALLOGRAFT_REJECTION-0.520
- IL6_JAK_STAT3_SIGNALING-0.510
- INTERFERON_GAMMA_RESPONSE-0.450
- INFLAMMATORY_RESPONSE-0.430
- E2F_TARGETS-0.420
- ANGIOGENESIS-0.410
- INTERFERON_ALPHA_RESPONSE-0.380
- MYOGENESIS-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR35579848 | — | B | 0.891 |
| 2 | MBCProject_0343_T1_RNA | — | B | 0.884 |
| 3 | SRR25617889 | — | B | 0.884 |
| 4 | DRR168565 | — | — | 0.879 |
| 5 | 1d0437fc-c8ad-47be-822d-b95ad10f0e4a | — | — | 0.870 |
| 6 | DRR168589 | — | — | 0.856 |
| 7 | MDT-AP-0180 | Med | Medulloblastoma | 0.856 |
| 8 | MDT-AP-2960 | Med | Medulloblastoma | 0.856 |
| 9 | SRR8943016 | — | — | 0.853 |
| 10 | TCGA-E2-A15G-01A-11R-A12D-07 | — | B | 0.845 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.380 | Remibrutinib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.270 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.150 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.140 | Cobimetinib | — uncovered |
| HEME_METABOLISM | 0.100 | Temsirolimus | — uncovered |
| PEROXISOME | 0.100 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.090 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.080 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.060 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.040 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.020 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.010 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.010 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.010 | Temsirolimus | — uncovered |