Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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1d0437fc-c8ad-47be-822d-b95ad10f0e4a

5a8796f7-bb7d-567c-925d-516d93934365

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Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
age_years
67.0390143737166

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR2016961
head-neck@1
0.891
2SRR975556
colon-landscapes@1
0.884
3SRR650196
bladder-landscape@3
0.870
4SRR25617889
breast-umap@18
B0.861
5SRR12475149
colon-landscapes@1
0.851
6C3L-03721
lung-landscapes@6
cohortA20.850
7TCGA-CF-A5U8-01A-11R-A28M-07
bladder-landscape@3
0.850
8SRR6079984
head-neck@1
0.848
9ERR2278853
head-neck@1
0.842
10eb67b977-b299-4bbc-b3f6-25d516473405
colon-landscapes@1
0.832

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 17 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.310Cobimetinib— uncovered
OXIDATIVE_PHOSPHORYLATION0.290Remibrutinib— uncovered
PROTEIN_SECRETION0.220Remibrutinib— uncovered
KRAS_SIGNALING_DN0.200Remibrutinib— uncovered
BILE_ACID_METABOLISM0.170Inavolisib— uncovered
FATTY_ACID_METABOLISM0.160Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.150Idelalisib— uncovered
ANDROGEN_RESPONSE0.140Inavolisib— uncovered
PEROXISOME0.140Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.120Inavolisib— uncovered
ADIPOGENESIS0.070Inavolisib— uncovered
APICAL_SURFACE0.060Temsirolimus— uncovered
NOTCH_SIGNALING0.030Inavolisib— uncovered
P53_PATHWAY0.020Idelalisib— uncovered
TGF_BETA_SIGNALING0.020Inavolisib— uncovered
HEME_METABOLISM0.010Temsirolimus— uncovered
SPERMATOGENESIS0.010Inavolisib— uncovered