Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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JAK2

RBC: JAK2 · Substrate: pEY ·

Top inhibitors

MeasuredDerived
DrugInhibition %Gini
Ruxolitinib100.00.59
Fedratinib99.40.58
Pralsetinib99.10.64
Entrectinib99.00.67
Midostaurin98.90.50
Crizotinib98.70.58
Pacritinib98.40.45
Repotrectinib98.30.61
Upadacitinib98.30.66
Ponatinib97.60.53
Baricitinib97.20.62
Alpelisib96.60.72
Umbralisib96.20.67
Defactinib95.30.45
Selpercatinib93.80.64

Known variants

Cancer associations

MutationCancer typeOrganSource
V617Fhaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
V617Fother_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
V617Fmalignant_melanoma_NSSkinhttps://doi.org/10.1093/nar/gkaa945
V617Fcarcinoma_lungLunghttps://doi.org/10.1093/nar/gkaa945
V617Flymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
V617Fcarcinoma_liverLiverhttps://doi.org/10.1093/nar/gkaa945
V617Fcarcinoma_thyroidThyroidhttps://doi.org/10.1093/nar/gkaa945
V617Fglioma_central_nervous_systemBrain/CNShttps://doi.org/10.1093/nar/gkaa945
V617Fcarcinoma_ovaryOvaryhttps://doi.org/10.1093/nar/gkaa945
V617FAML-USBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
V617FLAML-CNBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
V617FLAML-KRBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
V617FLIHC-USLiverhttps://doi.org/10.1093/nar/gkaa945
V617FLAMLBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
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