UniProt Q9Y243 · PDB · AlphaFold · Substrate: Crosstide · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Capivasertib | 98.5% | 1.5% | 96.48 | 0.644 |
| 2 | Netarsudil | 69.2% | 30.8% | 93.22 | 0.676 |
| 3 | Midostaurin | 39.9% | 60.1% | 78.64 | 0.500 |
| 4 | Leniolisib | 27.4% | 72.6% | 100.00 | 0.604 |
| 5 | Umbralisib | 25.9% | 74.1% | 98.74 | 0.670 |
| 6 | Selumetinib | 25.5% | 74.5% | 100.00 | 0.640 |
| 7 | Ponatinib | 21.2% | 78.8% | 78.23 | 0.534 |
| 8 | Tenalisib | 17.5% | 82.5% | 97.98 | 0.702 |
| 9 | Baricitinib | 16.7% | 83.3% | 97.99 | 0.616 |
| 10 | Ceritinib | 16.1% | 83.9% | 95.44 | 0.618 |
| 11 | Infigratinib | 13.5% | 86.5% | 98.24 | 0.710 |
| 12 | Apatinib | 13.3% | 86.7% | 97.73 | 0.704 |
| 13 | Paxalisib | 11.4% | 88.6% | 99.75 | 0.609 |
| 14 | Darovasertib | 11.2% | 88.8% | 96.99 | 0.719 |
| 15 | Pacritinib | 9.6% | 90.4% | 88.64 | 0.452 |
| 16 | Sunitinib | 9.6% | 90.4% | 91.73 | 0.524 |
| 17 | Acalabrutinib | 9.3% | 90.7% | 99.50 | 0.670 |
| 18 | Sorafenib | 8.8% | 91.2% | 96.72 | 0.776 |
| 19 | Pemigatinib | 8.6% | 91.4% | 98.23 | 0.718 |
| 20 | Mobocertinib | 8.6% | 91.4% | 97.22 | 0.757 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.46
- Epithelial log2(TPM+1): 1.87
- Fold change: 2.59
- Status: Upregulated
Selectivity landscape vs inhibition on AKT3
Each point is one of the 92 approved drugs; color = inhibition % on AKT3.
Mutation lollipop
Cancer-associated mutations plotted by residue position. Marker size + color scale with the number of distinct cancer reports.
Variants (2)
Mutation × cancer associations
| Mutation | Cancer | Organ | Source |
|---|---|---|---|
| E17K | malignant_melanoma_skin | Skin | ref |
| E17K | carcinoma_lung | Lung | ref |
| E17K | malignant_melanoma_NS | Skin | ref |
| E17K | carcinoma_prostate | Prostate | ref |
| E17K | carcinoma_thyroid | Thyroid | ref |
| E17K | leiomyosarcoma_soft_tissue | Soft Tissue | ref |
| E17K | carcinoma_penis | Genitourinary system | ref |
| E17K | carcinoma_kidney | Kidney | ref |
| E17K | KIRC-US | Kidney | ref |
| E17K | LUSC-US | Lung | ref |
| E17K | PBCA-DE | Pancreas | ref |
| E17K | SKCM-US | Skin | ref |
| E17K | KIRC | Kidney | ref |
| E17K | LUSC | Lung | ref |
| E17K | SKCM | Skin | ref |
| G171R | glioma_central_nervous_system | Brain/CNS | ref |
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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