CDK4/CCND3(CDK4/cyclin D3)
Sign in to save this workspaceUniProt CDK4: P11802; Cyclin D3: P30281 · PDB · AlphaFold (P11802), AlphaFold (P30281) · Substrate: RB Protein · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 100.0% | 0.0% | 91.48 | 0.563 |
| 2 | Palbociclib | 99.6% | 0.4% | 98.75 | 0.673 |
| 3 | Ribociclib | 98.6% | 1.4% | 99.25 | 0.729 |
| 4 | Pacritinib | 93.4% | 6.6% | 88.64 | 0.452 |
| 5 | Infigratinib | 59.4% | 40.6% | 98.24 | 0.710 |
| 6 | Defactinib | 58.8% | 41.2% | 92.68 | 0.450 |
| 7 | Brigatinib | 45.5% | 54.5% | 82.96 | 0.513 |
| 8 | Fedratinib | 41.7% | 58.3% | 96.21 | 0.576 |
| 9 | Gilteritinib | 36.6% | 63.4% | 88.97 | 0.506 |
| 10 | Vemurafenib | 33.1% | 66.9% | 96.49 | 0.598 |
| 11 | Dabrafenib | 28.9% | 71.1% | 94.74 | 0.633 |
| 12 | Nintedanib | 24.3% | 75.7% | 90.23 | 0.608 |
| 13 | Pazopanib | 23.2% | 76.8% | 97.49 | 0.672 |
| 14 | Pemigatinib | 20.8% | 79.2% | 98.23 | 0.718 |
| 15 | Ponatinib | 20.6% | 79.4% | 78.23 | 0.534 |
| 16 | Mitapivat | 20.2% | 79.8% | 100.00 | 0.625 |
| 17 | Ripretinib | 20.0% | 80.0% | 92.95 | 0.674 |
| 18 | Regorafenib | 19.3% | 80.7% | 95.99 | 0.719 |
| 19 | Avapritinib | 18.7% | 81.3% | 97.73 | 0.644 |
| 20 | Sunitinib | 18.0% | 82.0% | 91.73 | 0.524 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on CDK4/CCND3
Each point is one of the 92 approved drugs; color = inhibition % on CDK4/CCND3.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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