UniProt P23458 · PDB · AlphaFold · Substrate: pEY · Clone: aa 866-1154
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Pralsetinib | 99.1% | 0.9% | 93.43 | 0.643 |
| 2 | Abrocitinib | 98.7% | 1.3% | 99.50 | 0.581 |
| 3 | Baricitinib | 98.1% | 1.9% | 97.99 | 0.616 |
| 4 | Ponatinib | 98.0% | 2.0% | 78.23 | 0.534 |
| 5 | Upadacitinib | 97.3% | 2.6% | 97.98 | 0.663 |
| 6 | Repotrectinib | 96.9% | 3.1% | 84.21 | 0.608 |
| 7 | Ruxolitinib | 96.7% | 3.3% | 98.25 | 0.592 |
| 8 | Tenalisib | 96.4% | 3.6% | 97.98 | 0.702 |
| 9 | Umbralisib | 96.4% | 3.6% | 98.74 | 0.670 |
| 10 | Ripretinib | 96.0% | 4.0% | 92.95 | 0.674 |
| 11 | Tofacitinib | 95.2% | 4.8% | 99.25 | 0.684 |
| 12 | Fedratinib | 94.2% | 5.8% | 96.21 | 0.576 |
| 13 | Defactinib | 93.7% | 6.3% | 92.68 | 0.450 |
| 14 | Entrectinib | 93.3% | 6.7% | 93.69 | 0.671 |
| 15 | Tucatinib | 92.7% | 7.3% | 99.75 | 0.652 |
| 16 | Alpelisib | 92.2% | 7.8% | 97.22 | 0.720 |
| 17 | Apatinib | 88.7% | 11.3% | 97.73 | 0.704 |
| 18 | Pacritinib | 87.2% | 12.8% | 88.64 | 0.452 |
| 19 | Vemurafenib | 85.5% | 14.5% | 96.49 | 0.598 |
| 20 | Midostaurin | 85.3% | 14.7% | 78.64 | 0.500 |
Paralog block
JAK1, JAK2, JAK3
EMT expression
- Mesenchymal log2(TPM+1): 6.06
- Epithelial log2(TPM+1): 4.89
- Fold change: 1.17
- Status: Upregulated
Selectivity landscape vs inhibition on JAK1
Each point is one of the 92 approved drugs; color = inhibition % on JAK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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