UniProt O60307 · PDB · AlphaFold · Substrate: ARPP19 + Mn · Clone: aa1-723
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Pacritinib | 45.5% | 54.5% | 88.64 | 0.452 |
| 2 | Defactinib | 35.9% | 64.1% | 92.68 | 0.450 |
| 3 | Leniolisib | 18.0% | 82.0% | 100.00 | 0.604 |
| 4 | Umbralisib | 16.0% | 84.0% | 98.74 | 0.670 |
| 5 | Ponatinib | 14.1% | 85.9% | 78.23 | 0.534 |
| 6 | Paxalisib | 12.0% | 88.0% | 99.75 | 0.609 |
| 7 | Lazertinib | 11.9% | 88.1% | 97.47 | 0.674 |
| 8 | Pirtobrutinib | 11.5% | 88.5% | 99.49 | 0.656 |
| 9 | Infigratinib | 11.0% | 89.0% | 98.24 | 0.710 |
| 10 | Selumetinib | 10.6% | 89.4% | 100.00 | 0.640 |
| 11 | Pralsetinib | 9.9% | 90.1% | 93.43 | 0.643 |
| 12 | Neratinib | 8.1% | 91.9% | 93.18 | 0.597 |
| 13 | Ripretinib | 7.2% | 92.8% | 92.95 | 0.674 |
| 14 | Quizartinib | 6.7% | 93.3% | 99.50 | 0.737 |
| 15 | Canertinib | 6.6% | 93.4% | 96.49 | 0.671 |
| 16 | Apatinib | 6.6% | 93.4% | 97.73 | 0.704 |
| 17 | Capmatinib | 6.6% | 93.4% | 99.75 | 0.582 |
| 18 | Darovasertib | 5.5% | 94.5% | 96.99 | 0.719 |
| 19 | Crizotinib | 4.9% | 95.1% | 91.39 | 0.581 |
| 20 | Gedatolisib | 4.7% | 95.3% | 99.75 | 0.611 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 1.71
- Epithelial log2(TPM+1): 1.82
- Fold change: -0.11
- Status: No significant change
Selectivity landscape vs inhibition on MAST3
Each point is one of the 92 approved drugs; color = inhibition % on MAST3.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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