UniProt Q9H4B4 · PDB · AlphaFold · Substrate: Casein · Clone: Catalytic (58-340)
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Encorafenib | 21.8% | 78.2% | 98.50 | 0.755 |
| 2 | Ribociclib | 21.2% | 78.8% | 99.25 | 0.729 |
| 3 | Dabrafenib | 19.7% | 80.3% | 94.74 | 0.633 |
| 4 | Dacomitinib | 19.6% | 80.4% | 97.99 | 0.664 |
| 5 | Ibrutinib | 18.5% | 81.5% | 94.74 | 0.723 |
| 6 | Trametinib | 17.6% | 82.4% | 99.50 | 0.718 |
| 7 | Tofacitinib | 17.1% | 82.9% | 99.25 | 0.684 |
| 8 | Lorlatinib | 14.4% | 85.6% | 97.24 | 0.694 |
| 9 | Inavolisib | 13.2% | 86.8% | 100.00 | 0.679 |
| 10 | Leniolisib | 13.1% | 86.9% | 100.00 | 0.604 |
| 11 | Pazopanib | 12.8% | 87.2% | 97.49 | 0.672 |
| 12 | Duvelisib | 12.3% | 87.7% | 100.00 | 0.716 |
| 13 | Ripretinib | 12.2% | 87.8% | 92.95 | 0.674 |
| 14 | Infigratinib | 10.5% | 89.5% | 98.24 | 0.710 |
| 15 | Osimertinib | 10.4% | 89.6% | 97.24 | 0.733 |
| 16 | Apatinib | 10.4% | 89.6% | 97.73 | 0.704 |
| 17 | Pacritinib | 10.0% | 90.0% | 88.64 | 0.452 |
| 18 | Paxalisib | 9.7% | 90.3% | 99.75 | 0.609 |
| 19 | Pirtobrutinib | 9.6% | 90.4% | 99.49 | 0.656 |
| 20 | Selumetinib | 9.6% | 90.4% | 100.00 | 0.640 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 3.73
- Epithelial log2(TPM+1): 3.01
- Fold change: 0.73
- Status: No significant change
Selectivity landscape vs inhibition on PLK3
Each point is one of the 92 approved drugs; color = inhibition % on PLK3.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…