UniProt P57078 · PDB · AlphaFold · Substrate: Histone H2A · Clone: aa 1-300
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Quizartinib | 51.4% | 48.6% | 99.50 | 0.737 |
| 2 | Defactinib | 46.1% | 53.9% | 92.68 | 0.450 |
| 3 | Sorafenib | 39.4% | 60.6% | 96.72 | 0.776 |
| 4 | Ponatinib | 39.0% | 61.0% | 78.23 | 0.534 |
| 5 | Regorafenib | 36.3% | 63.7% | 95.99 | 0.719 |
| 6 | Tucatinib | 36.0% | 64.0% | 99.75 | 0.652 |
| 7 | Pexidartinib | 35.5% | 64.5% | 99.49 | 0.631 |
| 8 | Vemurafenib | 32.7% | 67.3% | 96.49 | 0.598 |
| 9 | Temsirolimus | 29.2% | 70.8% | 100.00 | 0.740 |
| 10 | Lapatinib | 28.9% | 71.1% | 99.25 | 0.616 |
| 11 | Lenvatinib | 21.3% | 78.7% | 97.74 | 0.726 |
| 12 | Umbralisib | 20.9% | 79.1% | 98.74 | 0.670 |
| 13 | Infigratinib | 20.0% | 80.0% | 98.24 | 0.710 |
| 14 | Gilteritinib | 20.0% | 80.0% | 88.97 | 0.506 |
| 15 | Nintedanib | 16.6% | 83.4% | 90.23 | 0.608 |
| 16 | Dabrafenib | 16.1% | 83.9% | 94.74 | 0.633 |
| 17 | Pacritinib | 15.8% | 84.2% | 88.64 | 0.452 |
| 18 | Selumetinib | 14.2% | 85.8% | 100.00 | 0.640 |
| 19 | Lazertinib | 14.1% | 85.9% | 97.47 | 0.674 |
| 20 | Apatinib | 14.1% | 85.9% | 97.73 | 0.704 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 1.72
- Epithelial log2(TPM+1): 2.58
- Fold change: -0.86
- Status: No significant change
Selectivity landscape vs inhibition on RIPK4
Each point is one of the 92 approved drugs; color = inhibition % on RIPK4.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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