TCGA-CF-A27C-01A-11R-A16R-07
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- overall_survival_months
- 13.96189225
- os_event
- false
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.100
- PEROXISOME+0.040
- ESTROGEN_RESPONSE_EARLY+0.000
- BILE_ACID_METABOLISM-0.070
- ESTROGEN_RESPONSE_LATE-0.070
- MYC_TARGETS_V2-0.070
- PROTEIN_SECRETION-0.070
- ANDROGEN_RESPONSE-0.080
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.080
- SPERMATOGENESIS-0.090
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.590
- E2F_TARGETS-0.520
- INFLAMMATORY_RESPONSE-0.490
- TNFA_SIGNALING_VIA_NFKB-0.490
- ANGIOGENESIS-0.460
- G2M_CHECKPOINT-0.430
- ALLOGRAFT_REJECTION-0.420
- IL2_STAT5_SIGNALING-0.420
- MTORC1_SIGNALING-0.390
- HEDGEHOG_SIGNALING-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | R247 | — | — | 0.920 |
| 2 | TCGA-CF-A5U8-01A-11R-A28M-07 | — | — | 0.904 |
| 3 | SRR8943008 | — | — | 0.903 |
| 4 | EPT0291 | EPN | EPN Tumor | 0.896 |
| 5 | TCGA-FD-A43X-01A-11R-A23W-07 | — | — | 0.890 |
| 6 | SRR23303775 | — | — | 0.886 |
| 7 | SRR650197 | — | — | 0.886 |
| 8 | TCGA-LT-A8JT-01A-11R-A36F-07 | — | — | 0.885 |
| 9 | C3N-03420 | — | cohortA1 | 0.883 |
| 10 | SRR12202498 | — | — | 0.882 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 2 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.100 | Remibrutinib | — uncovered |
| PEROXISOME | 0.040 | Idelalisib | — uncovered |