SRR1353157
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.434
- KRAS_SIGNALING_DN+0.302
- SPERMATOGENESIS+0.199
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.177
- HEDGEHOG_SIGNALING+0.152
- ADIPOGENESIS+0.080
- FATTY_ACID_METABOLISM+0.034
- MYOGENESIS+0.024
- BILE_ACID_METABOLISM+0.023
- PANCREAS_BETA_CELLS+0.015
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.535
- IL6_JAK_STAT3_SIGNALING-0.501
- INTERFERON_GAMMA_RESPONSE-0.494
- INFLAMMATORY_RESPONSE-0.493
- TNFA_SIGNALING_VIA_NFKB-0.470
- ANGIOGENESIS-0.430
- E2F_TARGETS-0.430
- G2M_CHECKPOINT-0.417
- ALLOGRAFT_REJECTION-0.406
- CHOLESTEROL_HOMEOSTASIS-0.378
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR657587 | GTEX | — | 0.970 |
| 2 | SRR1468381 | GTEX | — | 0.967 |
| 3 | SRR1478077 | GTEX | — | 0.965 |
| 4 | SRR1329377 | GTEX | — | 0.962 |
| 5 | SRR600560 | GTEX | — | 0.961 |
| 6 | SRR1357434 | GTEX | — | 0.961 |
| 7 | SRR1474065 | GTEX | — | 0.961 |
| 8 | SRR1340907 | GTEX | — | 0.957 |
| 9 | SRR1335651 | GTEX | — | 0.956 |
| 10 | SRR657348 | GTEX | — | 0.956 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.434 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.302 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.199 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.177 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.152 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.080 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.034 | Inavolisib | — uncovered |
| MYOGENESIS | 0.024 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.023 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.015 | Cobimetinib | — uncovered |
| PEROXISOME | 0.003 | Idelalisib | — uncovered |