SRR657587
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.498
- FATTY_ACID_METABOLISM+0.239
- SPERMATOGENESIS+0.227
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.208
- KRAS_SIGNALING_DN+0.204
- ADIPOGENESIS+0.203
- MYOGENESIS+0.109
- PEROXISOME+0.067
- HEDGEHOG_SIGNALING+0.061
- HEME_METABOLISM+0.060
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.497
- INTERFERON_GAMMA_RESPONSE-0.459
- IL6_JAK_STAT3_SIGNALING-0.456
- G2M_CHECKPOINT-0.431
- INFLAMMATORY_RESPONSE-0.425
- ANGIOGENESIS-0.415
- ALLOGRAFT_REJECTION-0.400
- E2F_TARGETS-0.389
- TNFA_SIGNALING_VIA_NFKB-0.353
- APOPTOSIS-0.347
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1353157 | GTEX | — | 0.970 |
| 2 | SRR659899 | GTEX | — | 0.966 |
| 3 | SRR1385124 | GTEX | — | 0.964 |
| 4 | SRR1415895 | GTEX | — | 0.952 |
| 5 | SRR1468381 | GTEX | — | 0.952 |
| 6 | SRR1096966 | GTEX | — | 0.942 |
| 7 | SRR657348 | GTEX | — | 0.939 |
| 8 | SRR600560 | GTEX | — | 0.935 |
| 9 | SRR1478077 | GTEX | — | 0.933 |
| 10 | SRR1357434 | GTEX | — | 0.933 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.498 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.239 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.227 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.208 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.204 | Remibrutinib | — uncovered |
| ADIPOGENESIS | 0.203 | Inavolisib | — uncovered |
| MYOGENESIS | 0.109 | Inavolisib | — uncovered |
| PEROXISOME | 0.067 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.061 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.060 | Temsirolimus | — uncovered |
| BILE_ACID_METABOLISM | 0.054 | Inavolisib | — uncovered |