SRR600560
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.434
- SPERMATOGENESIS+0.179
- HEDGEHOG_SIGNALING+0.146
- KRAS_SIGNALING_DN+0.135
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.100
- MYOGENESIS+0.092
- HEME_METABOLISM+0.002
- PEROXISOME-0.010
- MYC_TARGETS_V2-0.026
- FATTY_ACID_METABOLISM-0.071
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.519
- ANGIOGENESIS-0.477
- INTERFERON_GAMMA_RESPONSE-0.453
- INFLAMMATORY_RESPONSE-0.451
- IL6_JAK_STAT3_SIGNALING-0.412
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.407
- G2M_CHECKPOINT-0.407
- E2F_TARGETS-0.395
- TNFA_SIGNALING_VIA_NFKB-0.384
- APOPTOSIS-0.366
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1353157 | GTEX | — | 0.961 |
| 2 | SRR1474065 | GTEX | — | 0.961 |
| 3 | SRR1376597 | GTEX | — | 0.958 |
| 4 | SRR1478077 | GTEX | — | 0.956 |
| 5 | SRR1370619 | GTEX | — | 0.955 |
| 6 | SRR1322555 | GTEX | — | 0.955 |
| 7 | SRR1385124 | GTEX | — | 0.950 |
| 8 | SRR1500753 | GTEX | — | 0.948 |
| 9 | SRR1453341 | GTEX | — | 0.946 |
| 10 | SRR1432123 | GTEX | — | 0.945 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.434 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.179 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.146 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.135 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.100 | Inavolisib | — uncovered |
| MYOGENESIS | 0.092 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.002 | Temsirolimus | — uncovered |