MBCProject_4647_T0_RNA
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.580
- INTERFERON_GAMMA_RESPONSE+0.280
- ESTROGEN_RESPONSE_EARLY+0.190
- MYC_TARGETS_V2+0.160
- DNA_REPAIR+0.090
- E2F_TARGETS+0.050
- G2M_CHECKPOINT+0.020
- KRAS_SIGNALING_DN-0.010
- MITOTIC_SPINDLE-0.010
- ALLOGRAFT_REJECTION-0.020
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.530
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.460
- COAGULATION-0.450
- OXIDATIVE_PHOSPHORYLATION-0.440
- ANGIOGENESIS-0.420
- FATTY_ACID_METABOLISM-0.420
- KRAS_SIGNALING_UP-0.400
- MYC_TARGETS_V1-0.390
- PROTEIN_SECRETION-0.390
- CHOLESTEROL_HOMEOSTASIS-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 20040121.LumB | — | D | 0.854 |
| 2 | TCGA-60-2721-01A-01R-0851-07 | — | cohortSQ1 | 0.844 |
| 3 | SRR33532821 | — | D | 0.843 |
| 4 | AUR-AF9A-TTP1-A-1-0-R-A741-41 | — | D | 0.840 |
| 5 | SRR1313108 | — | B | 0.839 |
| 6 | SRR33532764 | — | D | 0.824 |
| 7 | SRR35579810 | — | B | 0.823 |
| 8 | SRR8613722 | — | E | 0.819 |
| 9 | SRR6013553 | — | cohortA3 | 0.810 |
| 10 | SRR35579841 | — | B | 0.806 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.580 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.280 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.190 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.160 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.090 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.050 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.020 | Inavolisib | — uncovered |