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SRR1313108

· B

5ba0b807-ec68-5135-ada2-4fab8a1eecb5

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • DNA_REPAIR+0.070
  • INTERFERON_ALPHA_RESPONSE+0.060
  • MITOTIC_SPINDLE+0.060
  • SPERMATOGENESIS+0.060
  • BILE_ACID_METABOLISM+0.000
  • ESTROGEN_RESPONSE_LATE+0.000
  • ESTROGEN_RESPONSE_EARLY-0.030
  • HEDGEHOG_SIGNALING-0.060
  • KRAS_SIGNALING_DN-0.060
  • MYC_TARGETS_V2-0.100

Top 10 suppressed

  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.570
  • ANGIOGENESIS-0.470
  • MTORC1_SIGNALING-0.460
  • MYC_TARGETS_V1-0.460
  • TNFA_SIGNALING_VIA_NFKB-0.450
  • ANDROGEN_RESPONSE-0.420
  • CHOLESTEROL_HOMEOSTASIS-0.410
  • OXIDATIVE_PHOSPHORYLATION-0.410
  • PROTEIN_SECRETION-0.400
  • INFLAMMATORY_RESPONSE-0.390

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR23303775
bladder-landscape@3
0.916
220040121.LumB
breast-umap@18
D0.910
320050097.LumA
breast-umap@18
B0.909
4SRR1313096
breast-umap@18
B0.905
5SRR650134
bladder-landscape@3
0.896
6SRR664854
brain-umap@2
GTEX0.896
7SRR1388504
brain-umap@2
GTEX0.892
8SRR25617904
breast-umap@18
B0.891
9TCGA-L9-A7SV-01A-11R-A39D-07
lung-landscapes@6
cohortA10.891
10MNG1271
mng-umap@100
0.891

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
DNA_REPAIR0.070Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.060Inavolisib— uncovered
MITOTIC_SPINDLE0.060Inavolisib— uncovered
SPERMATOGENESIS0.060Inavolisib— uncovered