SRR35579841
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ESTROGEN_RESPONSE_EARLY+0.220
- INTERFERON_ALPHA_RESPONSE+0.200
- ALLOGRAFT_REJECTION+0.140
- KRAS_SIGNALING_DN+0.140
- DNA_REPAIR+0.130
- ESTROGEN_RESPONSE_LATE+0.090
- PEROXISOME+0.070
- BILE_ACID_METABOLISM+0.060
- INTERFERON_GAMMA_RESPONSE+0.020
- WNT_BETA_CATENIN_SIGNALING+0.010
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.550
- ANGIOGENESIS-0.490
- PROTEIN_SECRETION-0.490
- TGF_BETA_SIGNALING-0.430
- MTORC1_SIGNALING-0.420
- ANDROGEN_RESPONSE-0.390
- HYPOXIA-0.380
- KRAS_SIGNALING_UP-0.330
- TNFA_SIGNALING_VIA_NFKB-0.330
- UV_RESPONSE_DN-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 20050097.LumA | — | B | 0.881 |
| 2 | SRR33532821 | — | D | 0.864 |
| 3 | TCGA-OL-A5D8-01A-11R-A27Q-07 | — | B | 0.852 |
| 4 | SRR1313108 | — | B | 0.843 |
| 5 | TCGA-EW-A423-01A-11R-A24H-07 | — | B | 0.816 |
| 6 | R87 | — | — | 0.813 |
| 7 | SJEPD019_D.RNA-Seq | EPN | Posterior Fossa EPN | 0.811 |
| 8 | TCGA-MP-A4T6-01A-32R-A262-07 | — | cohortA1 | 0.811 |
| 9 | MBCProject_4647_T0_RNA | — | B | 0.806 |
| 10 | MNG1106 | — | — | 0.803 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ESTROGEN_RESPONSE_EARLY | 0.220 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.200 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.140 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.140 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.130 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.090 | Idelalisib | — uncovered |
| PEROXISOME | 0.070 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.060 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.020 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.010 | Inavolisib | — uncovered |