MBCProject_5782_T1_RNA
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- UV_RESPONSE_DN+0.220
- MITOTIC_SPINDLE+0.120
- HEDGEHOG_SIGNALING+0.090
- PANCREAS_BETA_CELLS+0.090
- WNT_BETA_CATENIN_SIGNALING+0.070
- SPERMATOGENESIS+0.060
- BILE_ACID_METABOLISM+0.020
- ESTROGEN_RESPONSE_EARLY+0.020
- NOTCH_SIGNALING-0.010
- ANDROGEN_RESPONSE-0.020
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- MTORC1_SIGNALING-0.390
- UV_RESPONSE_UP-0.360
- E2F_TARGETS-0.340
- GLYCOLYSIS-0.330
- INTERFERON_ALPHA_RESPONSE-0.320
- PI3K_AKT_MTOR_SIGNALING-0.320
- HYPOXIA-0.310
- P53_PATHWAY-0.300
- CHOLESTEROL_HOMEOSTASIS-0.290
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR8518450 | — | A | 0.884 |
| 2 | TCGA-A7-A0DC-01B-04R-A22O-07 | — | D | 0.881 |
| 3 | SRR11296800 | — | — | 0.879 |
| 4 | TCGA-A7-A13G-01B-04R-A22O-07 | — | D | 0.873 |
| 5 | s0102877 | — | — | 0.865 |
| 6 | C3N-03420 | — | cohortA1 | 0.865 |
| 7 | MBCProject_0719_T1_RNA | — | A | 0.864 |
| 8 | SAMN03290913 | — | — | 0.864 |
| 9 | AUR-AFUN-TTP1-A-1-0-R-A741-41 | — | D | 0.861 |
| 10 | BS_0Y66ZBWE | low-grade glioma | — | 0.860 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| UV_RESPONSE_DN | 0.220 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.120 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.090 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.090 | Cobimetinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.070 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.060 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.020 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.020 | Inavolisib | — uncovered |