MNG1271

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26a6b2b3-5fa6-5946-bf66-874485ee88f5

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

MITOTIC_SPINDLE+0.025
PI3K_AKT_MTOR_SIGNALING+0.024
KRAS_SIGNALING_DN+0.003
SPERMATOGENESIS-0.028
DNA_REPAIR-0.038
HEME_METABOLISM-0.042
BILE_ACID_METABOLISM-0.060
MYC_TARGETS_V2-0.063
APICAL_JUNCTION-0.071
P53_PATHWAY-0.096

Top 10 suppressed

ANGIOGENESIS-0.512
HEDGEHOG_SIGNALING-0.491
EPITHELIAL_MESENCHYMAL_TRANSITION-0.439
ANDROGEN_RESPONSE-0.393
CHOLESTEROL_HOMEOSTASIS-0.389
NOTCH_SIGNALING-0.380
HYPOXIA-0.354
TNFA_SIGNALING_VIA_NFKB-0.335
UV_RESPONSE_DN-0.328
ALLOGRAFT_REJECTION-0.322

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR23303775 bladder-landscape@3	—	—	0.917
2	SRR650134 bladder-landscape@3	—	—	0.914
3	20050097.LumA breast-umap@18	—	B	0.891
4	SRR1313108 breast-umap@18	—	B	0.891
5	TCGA-L9-A7SV-01A-11R-A39D-07 lung-landscapes@6	—	cohortA1	0.890
6	SRR607967 brain-umap@2	GTEX	—	0.888
7	SRR1328960 brain-umap@2	GTEX	—	0.887
8	SRR1467255 brain-umap@2	GTEX	—	0.886
9	SRR1313096 breast-umap@18	—	B	0.885
10	SRR627433 brain-umap@2	GTEX	—	0.885

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 3 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
MITOTIC_SPINDLE	0.025	Inavolisib	— uncovered
PI3K_AKT_MTOR_SIGNALING	0.024	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.003	Remibrutinib	— uncovered