20050097.LumA
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ESTROGEN_RESPONSE_EARLY+0.150
- DNA_REPAIR+0.110
- ESTROGEN_RESPONSE_LATE+0.100
- BILE_ACID_METABOLISM-0.010
- FATTY_ACID_METABOLISM-0.050
- SPERMATOGENESIS-0.060
- KRAS_SIGNALING_DN-0.070
- PEROXISOME-0.090
- APICAL_SURFACE-0.100
- HEME_METABOLISM-0.110
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.650
- MYC_TARGETS_V1-0.500
- ANGIOGENESIS-0.480
- PROTEIN_SECRETION-0.480
- HEDGEHOG_SIGNALING-0.440
- ANDROGEN_RESPONSE-0.390
- MTORC1_SIGNALING-0.390
- UV_RESPONSE_DN-0.390
- UNFOLDED_PROTEIN_RESPONSE-0.370
- CHOLESTEROL_HOMEOSTASIS-0.360
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | R87 | — | — | 0.914 |
| 2 | SRR1313108 | — | B | 0.909 |
| 3 | MNG1271 | — | — | 0.891 |
| 4 | a3380ca6-6c65-4543-9bdf-957b26c1daaf | — | — | 0.888 |
| 5 | SRR35579841 | — | B | 0.881 |
| 6 | ERR2278876 | — | — | 0.873 |
| 7 | TCGA-E2-A2P6-01A-11R-A19W-07 | — | B | 0.871 |
| 8 | SRR2016945 | — | — | 0.870 |
| 9 | TCGA-EW-A423-01A-11R-A24H-07 | — | B | 0.869 |
| 10 | SRR23303775 | — | — | 0.868 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 3 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ESTROGEN_RESPONSE_EARLY | 0.150 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.110 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.100 | Idelalisib | — uncovered |