SRR1318407
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYOGENESIS+0.237
- MYC_TARGETS_V2+0.162
- DNA_REPAIR+0.151
- KRAS_SIGNALING_DN+0.115
- WNT_BETA_CATENIN_SIGNALING+0.085
- MITOTIC_SPINDLE+0.028
- SPERMATOGENESIS+0.022
- APICAL_JUNCTION+0.017
- P53_PATHWAY-0.044
- HEME_METABOLISM-0.054
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.466
- INFLAMMATORY_RESPONSE-0.460
- INTERFERON_GAMMA_RESPONSE-0.458
- ALLOGRAFT_REJECTION-0.447
- ANGIOGENESIS-0.443
- TGF_BETA_SIGNALING-0.436
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.424
- KRAS_SIGNALING_UP-0.418
- COAGULATION-0.417
- TNFA_SIGNALING_VIA_NFKB-0.394
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1499982 | GTEX | — | 0.961 |
| 2 | SRR1415215 | GTEX | — | 0.958 |
| 3 | SRR1440119 | GTEX | — | 0.956 |
| 4 | SRR1471417 | GTEX | — | 0.956 |
| 5 | SRR1464305 | GTEX | — | 0.954 |
| 6 | SRR1489054 | GTEX | — | 0.954 |
| 7 | SRR1359367 | GTEX | — | 0.953 |
| 8 | SRR1327811 | GTEX | — | 0.952 |
| 9 | SRR1417981 | GTEX | — | 0.951 |
| 10 | SRR1398839 | GTEX | — | 0.951 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYOGENESIS | 0.237 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.162 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.151 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.115 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.085 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.028 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.022 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.017 | Inavolisib | — uncovered |