SRR2757338
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- CHOLESTEROL_HOMEOSTASIS+0.200
- KRAS_SIGNALING_DN+0.200
- NOTCH_SIGNALING+0.200
- HEDGEHOG_SIGNALING+0.100
- MYC_TARGETS_V2+0.100
- APICAL_SURFACE+0.000
- DNA_REPAIR+0.000
- FATTY_ACID_METABOLISM+0.000
- MYOGENESIS+0.000
- PEROXISOME+0.000
Top 10 suppressed
- ANGIOGENESIS-0.400
- APOPTOSIS-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- PI3K_AKT_MTOR_SIGNALING-0.400
- PROTEIN_SECRETION-0.400
- ALLOGRAFT_REJECTION-0.300
- ANDROGEN_RESPONSE-0.300
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.300
- ESTROGEN_RESPONSE_EARLY-0.300
- ESTROGEN_RESPONSE_LATE-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1797247 | — | cohortSC | 0.869 |
| 2 | MNG851 | — | — | 0.856 |
| 3 | MNG857 | — | — | 0.854 |
| 4 | SRR25617924 | — | D | 0.850 |
| 5 | SRR12202498 | — | — | 0.850 |
| 6 | TCGA-L9-A7SV-01A-11R-A39D-07 | — | cohortA1 | 0.847 |
| 7 | TCGA-E5-A4U1-01A-11R-A31N-07 | — | — | 0.844 |
| 8 | SRR23303752 | — | — | 0.841 |
| 9 | SRR1350107 | GTEX | — | 0.841 |
| 10 | SRR1797238 | — | cohortSC | 0.838 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| CHOLESTEROL_HOMEOSTASIS | 0.200 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.200 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.200 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.100 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.100 | Idelalisib | — uncovered |