SRR1465132
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.135
- SPERMATOGENESIS+0.057
- DNA_REPAIR+0.043
- PI3K_AKT_MTOR_SIGNALING-0.021
- PROTEIN_SECRETION-0.029
- MITOTIC_SPINDLE-0.031
- PANCREAS_BETA_CELLS-0.068
- E2F_TARGETS-0.069
- MYC_TARGETS_V1-0.077
- UNFOLDED_PROTEIN_RESPONSE-0.078
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.522
- INTERFERON_GAMMA_RESPONSE-0.452
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.418
- COMPLEMENT-0.417
- TNFA_SIGNALING_VIA_NFKB-0.414
- ALLOGRAFT_REJECTION-0.409
- COAGULATION-0.406
- INFLAMMATORY_RESPONSE-0.404
- APOPTOSIS-0.397
- KRAS_SIGNALING_UP-0.382
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1338323 | GTEX | — | 0.983 |
| 2 | SRR1431366 | GTEX | — | 0.981 |
| 3 | SRR1429935 | GTEX | — | 0.981 |
| 4 | SRR1439850 | GTEX | — | 0.980 |
| 5 | SRR1331841 | GTEX | — | 0.978 |
| 6 | SRR1324452 | GTEX | — | 0.977 |
| 7 | SRR1384234 | GTEX | — | 0.975 |
| 8 | SRR1338669 | GTEX | — | 0.975 |
| 9 | SRR1402513 | GTEX | — | 0.975 |
| 10 | SRR1348021 | GTEX | — | 0.975 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 3 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.135 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.057 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.043 | Idelalisib | — uncovered |