SRR1331944
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.147
- MYOGENESIS+0.123
- PI3K_AKT_MTOR_SIGNALING+0.071
- UNFOLDED_PROTEIN_RESPONSE+0.068
- KRAS_SIGNALING_DN+0.051
- OXIDATIVE_PHOSPHORYLATION+0.049
- PROTEIN_SECRETION+0.034
- UV_RESPONSE_UP+0.024
- MYC_TARGETS_V2+0.023
- SPERMATOGENESIS+0.014
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.567
- INTERFERON_GAMMA_RESPONSE-0.439
- IL6_JAK_STAT3_SIGNALING-0.423
- INFLAMMATORY_RESPONSE-0.423
- ALLOGRAFT_REJECTION-0.363
- KRAS_SIGNALING_UP-0.361
- TNFA_SIGNALING_VIA_NFKB-0.356
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.334
- COAGULATION-0.331
- COMPLEMENT-0.315
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1401062 | GTEX | — | 0.969 |
| 2 | SRR1361736 | GTEX | — | 0.968 |
| 3 | SRR1490568 | GTEX | — | 0.967 |
| 4 | SRR1359367 | GTEX | — | 0.966 |
| 5 | SRR1464305 | GTEX | — | 0.965 |
| 6 | SRR817190 | GTEX | — | 0.962 |
| 7 | SRR1417981 | GTEX | — | 0.959 |
| 8 | SRR1456531 | GTEX | — | 0.959 |
| 9 | SRR1471417 | GTEX | — | 0.958 |
| 10 | SRR659412 | GTEX | — | 0.957 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.147 | Idelalisib | — uncovered |
| MYOGENESIS | 0.123 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.071 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.068 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.051 | Remibrutinib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.049 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.034 | Remibrutinib | — uncovered |
| UV_RESPONSE_UP | 0.024 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.023 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.014 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.010 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.001 | Inavolisib | — uncovered |