SRR1359192
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.395
- SPERMATOGENESIS+0.362
- HEDGEHOG_SIGNALING+0.246
- KRAS_SIGNALING_DN+0.225
- PANCREAS_BETA_CELLS+0.186
- PROTEIN_SECRETION+0.058
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.051
- MYOGENESIS+0.046
- UV_RESPONSE_DN+0.023
- ADIPOGENESIS+0.004
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.559
- IL6_JAK_STAT3_SIGNALING-0.536
- INTERFERON_GAMMA_RESPONSE-0.477
- CHOLESTEROL_HOMEOSTASIS-0.384
- INFLAMMATORY_RESPONSE-0.371
- ANGIOGENESIS-0.360
- TNFA_SIGNALING_VIA_NFKB-0.359
- E2F_TARGETS-0.330
- IL2_STAT5_SIGNALING-0.330
- G2M_CHECKPOINT-0.329
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1474065 | GTEX | — | 0.964 |
| 2 | SRR1389979 | GTEX | — | 0.958 |
| 3 | SRR657348 | GTEX | — | 0.953 |
| 4 | SRR1439873 | GTEX | — | 0.952 |
| 5 | SRR1353157 | GTEX | — | 0.951 |
| 6 | SRR1464373 | GTEX | — | 0.951 |
| 7 | SRR1322555 | GTEX | — | 0.950 |
| 8 | SRR1459718 | GTEX | — | 0.950 |
| 9 | SRR1084842 | GTEX | — | 0.947 |
| 10 | SRR1474553 | GTEX | — | 0.947 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.395 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.362 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.246 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.225 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.186 | Cobimetinib | — uncovered |
| PROTEIN_SECRETION | 0.058 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.051 | Inavolisib | — uncovered |
| MYOGENESIS | 0.046 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.023 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.004 | Inavolisib | — uncovered |