SRR1434803
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.249
- KRAS_SIGNALING_DN+0.061
- MYC_TARGETS_V2+0.052
- UNFOLDED_PROTEIN_RESPONSE+0.044
- MITOTIC_SPINDLE+0.040
- MYOGENESIS+0.017
- MYC_TARGETS_V1-0.007
- SPERMATOGENESIS-0.007
- OXIDATIVE_PHOSPHORYLATION-0.026
- APICAL_JUNCTION-0.044
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.510
- TNFA_SIGNALING_VIA_NFKB-0.484
- INFLAMMATORY_RESPONSE-0.463
- INTERFERON_GAMMA_RESPONSE-0.463
- NOTCH_SIGNALING-0.451
- IL6_JAK_STAT3_SIGNALING-0.448
- ALLOGRAFT_REJECTION-0.444
- COAGULATION-0.437
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.436
- KRAS_SIGNALING_UP-0.424
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1360038 | GTEX | — | 0.985 |
| 2 | SRR1499982 | GTEX | — | 0.984 |
| 3 | SRR1440119 | GTEX | — | 0.981 |
| 4 | SRR1401552 | GTEX | — | 0.980 |
| 5 | SRR1464305 | GTEX | — | 0.979 |
| 6 | SRR1490568 | GTEX | — | 0.978 |
| 7 | SRR1319672 | GTEX | — | 0.977 |
| 8 | SRR1352415 | GTEX | — | 0.976 |
| 9 | SRR1356204 | GTEX | — | 0.976 |
| 10 | SRR817190 | GTEX | — | 0.976 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.249 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.061 | Remibrutinib | — uncovered |
| MYC_TARGETS_V2 | 0.052 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.044 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.040 | Inavolisib | — uncovered |
| MYOGENESIS | 0.017 | Inavolisib | — uncovered |