SRR8943023
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- TGF_BETA_SIGNALING+0.480
- PROTEIN_SECRETION+0.290
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.220
- INTERFERON_ALPHA_RESPONSE+0.200
- NOTCH_SIGNALING+0.190
- P53_PATHWAY+0.140
- WNT_BETA_CATENIN_SIGNALING+0.120
- HEME_METABOLISM+0.110
- DNA_REPAIR+0.070
- UV_RESPONSE_DN+0.070
Top 10 suppressed
- E2F_TARGETS-0.510
- G2M_CHECKPOINT-0.450
- APICAL_SURFACE-0.380
- ALLOGRAFT_REJECTION-0.370
- INFLAMMATORY_RESPONSE-0.320
- KRAS_SIGNALING_UP-0.290
- TNFA_SIGNALING_VIA_NFKB-0.280
- IL2_STAT5_SIGNALING-0.270
- KRAS_SIGNALING_DN-0.260
- IL6_JAK_STAT3_SIGNALING-0.250
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12202454 | — | — | 0.829 |
| 2 | SRR1516088 | — | — | 0.788 |
| 3 | R229 | — | — | 0.761 |
| 4 | BS_SXCZ3CXN | Embryonal tumors | — | 0.738 |
| 5 | SRR23303735 | — | — | 0.730 |
| 6 | SRR12202458 | — | — | 0.705 |
| 7 | SRR25043615 | — | — | 0.705 |
| 8 | TCGA-DK-A1AA-01A-11R-A13Y-07 | — | — | 0.704 |
| 9 | SRR8942997 | — | — | 0.700 |
| 10 | SRR8942980 | — | — | 0.692 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| TGF_BETA_SIGNALING | 0.480 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.290 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.220 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.200 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.190 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.140 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.120 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.110 | Temsirolimus | — uncovered |
| DNA_REPAIR | 0.070 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.070 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.060 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.050 | Inavolisib | — uncovered |
| COAGULATION | 0.020 | Binimetinib | — uncovered |