SRR8518194
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.130
- E2F_TARGETS+0.110
- MYC_TARGETS_V2+0.110
- DNA_REPAIR+0.080
- G2M_CHECKPOINT+0.070
- MITOTIC_SPINDLE+0.060
- FATTY_ACID_METABOLISM+0.020
- SPERMATOGENESIS+0.000
- PROTEIN_SECRETION-0.020
- MYC_TARGETS_V1-0.040
Top 10 suppressed
- ANGIOGENESIS-0.560
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.560
- INTERFERON_ALPHA_RESPONSE-0.550
- TNFA_SIGNALING_VIA_NFKB-0.480
- COAGULATION-0.450
- INTERFERON_GAMMA_RESPONSE-0.450
- INFLAMMATORY_RESPONSE-0.440
- HYPOXIA-0.410
- PANCREAS_BETA_CELLS-0.410
- APICAL_SURFACE-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
0 twins match this tumor's tissue · 10 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1385036 | GTEX | — | 0.933 |
| 2 | SRR1456841 | GTEX | — | 0.927 |
| 3 | SRR659412 | GTEX | — | 0.926 |
| 4 | SRR1357413 | GTEX | — | 0.923 |
| 5 | SRR613366 | GTEX | — | 0.921 |
| 6 | SRR655864 | GTEX | — | 0.920 |
| 7 | SRR1456531 | GTEX | — | 0.920 |
| 8 | SRR1500537 | GTEX | — | 0.920 |
| 9 | SRR1360038 | GTEX | — | 0.919 |
| 10 | SRR1464305 | GTEX | — | 0.918 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.130 | Remibrutinib | — uncovered |
| E2F_TARGETS | 0.110 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.110 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.080 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.070 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.060 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.020 | Inavolisib | — uncovered |