C3L-04759
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 67.82477755
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- BILE_ACID_METABOLISM+0.200
- HEDGEHOG_SIGNALING+0.120
- PROTEIN_SECRETION+0.120
- INTERFERON_ALPHA_RESPONSE+0.080
- NOTCH_SIGNALING+0.030
- TGF_BETA_SIGNALING+0.030
- UV_RESPONSE_DN+0.020
- ANGIOGENESIS-0.010
- KRAS_SIGNALING_UP-0.030
- MYOGENESIS-0.030
Top 10 suppressed
- E2F_TARGETS-0.570
- G2M_CHECKPOINT-0.540
- MYC_TARGETS_V1-0.510
- MYC_TARGETS_V2-0.480
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.470
- OXIDATIVE_PHOSPHORYLATION-0.440
- MTORC1_SIGNALING-0.420
- HYPOXIA-0.410
- GLYCOLYSIS-0.390
- P53_PATHWAY-0.370
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-3267 | Med | Medulloblastoma | 0.908 |
| 2 | TCGA-A7-A13G-01B-04R-A22O-07 | — | D | 0.888 |
| 3 | SRR8526730 | — | cohortA1 | 0.877 |
| 4 | C3N-00293 | — | cohortA1 | 0.871 |
| 5 | SRR23303736 | — | — | 0.867 |
| 6 | 3ca8899d-3ed3-478b-a70c-919f68969d81 | — | — | 0.858 |
| 7 | SRR1313120 | — | A | 0.855 |
| 8 | TCGA-E2-A15I-01A-21R-A137-07 | — | B | 0.851 |
| 9 | SRR11296732 | — | — | 0.851 |
| 10 | MDT-AP-0734 | Med | Medulloblastoma | 0.848 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| BILE_ACID_METABOLISM | 0.200 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.120 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.120 | Remibrutinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.080 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.030 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.030 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.020 | Inavolisib | — uncovered |