SRR661005
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.311
- HEDGEHOG_SIGNALING+0.282
- UV_RESPONSE_DN+0.214
- KRAS_SIGNALING_DN+0.203
- MYOGENESIS+0.138
- BILE_ACID_METABOLISM+0.122
- SPERMATOGENESIS+0.102
- APICAL_SURFACE+0.080
- INTERFERON_GAMMA_RESPONSE+0.076
- PROTEIN_SECRETION+0.071
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.512
- MYC_TARGETS_V2-0.489
- OXIDATIVE_PHOSPHORYLATION-0.470
- MYC_TARGETS_V1-0.437
- DNA_REPAIR-0.378
- TNFA_SIGNALING_VIA_NFKB-0.361
- UNFOLDED_PROTEIN_RESPONSE-0.344
- ALLOGRAFT_REJECTION-0.335
- MTORC1_SIGNALING-0.328
- E2F_TARGETS-0.282
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR659602 | GTEX | — | 0.904 |
| 2 | C3N-03057 | — | cohortA1 | 0.834 |
| 3 | MDT-AP-3326 | Med | Medulloblastoma | 0.823 |
| 4 | SRR11296732 | — | — | 0.822 |
| 5 | MDT-AP-3267 | Med | Medulloblastoma | 0.815 |
| 6 | SRR5088913 | — | — | 0.815 |
| 7 | SRR1466641 | GTEX | — | 0.812 |
| 8 | MNG957 | — | — | 0.811 |
| 9 | MDT-AP-0810 | Med | Medulloblastoma | 0.810 |
| 10 | MNG858 | — | — | 0.807 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.311 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.282 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.214 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.203 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.138 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.122 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.102 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.080 | Temsirolimus | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.076 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.071 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.045 | Temsirolimus | — uncovered |
| FATTY_ACID_METABOLISM | 0.038 | Inavolisib | — uncovered |