C3L-04031
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 73.26488706
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.230
- PANCREAS_BETA_CELLS+0.180
- INTERFERON_ALPHA_RESPONSE+0.150
- KRAS_SIGNALING_DN+0.150
- BILE_ACID_METABOLISM+0.080
- GLYCOLYSIS+0.080
- UNFOLDED_PROTEIN_RESPONSE+0.040
- PEROXISOME+0.000
- COAGULATION-0.010
- HEME_METABOLISM-0.020
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.390
- G2M_CHECKPOINT-0.380
- WNT_BETA_CATENIN_SIGNALING-0.380
- APICAL_SURFACE-0.360
- E2F_TARGETS-0.360
- NOTCH_SIGNALING-0.350
- TNFA_SIGNALING_VIA_NFKB-0.320
- COMPLEMENT-0.300
- DNA_REPAIR-0.300
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR33346946 | — | — | 0.813 |
| 2 | 0b5850f2-648a-4dad-a48d-82150c12acb4 | — | — | 0.808 |
| 3 | s0095165 | — | — | 0.797 |
| 4 | MNG346 | — | — | 0.791 |
| 5 | SRR25617833 | — | B | 0.785 |
| 6 | R11 | — | — | 0.778 |
| 7 | SRR12202498 | — | — | 0.774 |
| 8 | TCGA-ZF-A9R5-01A-12R-A42T-07 | — | — | 0.769 |
| 9 | TCGA-CF-A27C-01A-11R-A16R-07 | — | — | 0.763 |
| 10 | sclc265549_S73.txt | — | cohortMD1 | 0.760 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.230 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.180 | Cobimetinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.150 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.150 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.080 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.080 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.040 | Idelalisib | — uncovered |