ULC1485T_S59
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.170
- INTERFERON_GAMMA_RESPONSE+0.160
- CHOLESTEROL_HOMEOSTASIS+0.120
- UV_RESPONSE_DN+0.090
- ANDROGEN_RESPONSE+0.080
- HEDGEHOG_SIGNALING+0.050
- PEROXISOME+0.050
- INTERFERON_ALPHA_RESPONSE+0.030
- KRAS_SIGNALING_DN+0.010
- IL6_JAK_STAT3_SIGNALING+0.000
Top 10 suppressed
- ANGIOGENESIS-0.400
- MYC_TARGETS_V1-0.350
- OXIDATIVE_PHOSPHORYLATION-0.310
- GLYCOLYSIS-0.300
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.300
- ADIPOGENESIS-0.280
- HYPOXIA-0.280
- G2M_CHECKPOINT-0.270
- E2F_TARGETS-0.260
- MTORC1_SIGNALING-0.250
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2208971 | — | — | 0.818 |
| 2 | SRR8526730 | — | cohortA1 | 0.816 |
| 3 | C3N-01799 | — | cohortA1 | 0.804 |
| 4 | TCGA-NJ-A55A-01A-11R-A262-07 | — | cohortA1 | 0.775 |
| 5 | TCGA-95-A4VK-01A-11R-A262-07 | — | cohortA4 | 0.771 |
| 6 | SRR6013487 | — | cohortA1 | 0.769 |
| 7 | TCGA-55-A48X-01A-11R-A24H-07 | — | cohortA1 | 0.768 |
| 8 | ERR2208899 | — | — | 0.767 |
| 9 | AUR-AFSP-TTP1-A-8-0-R-A741-41 | — | D | 0.760 |
| 10 | 88448 | EPN | Supratentorial EPN | 0.760 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.170 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.160 | Idelalisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.120 | Remibrutinib | — uncovered |
| UV_RESPONSE_DN | 0.090 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.080 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.050 | Inavolisib | — uncovered |
| PEROXISOME | 0.050 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.030 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.010 | Remibrutinib | — uncovered |