a3380ca6-6c65-4543-9bdf-957b26c1daaf
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 66.4175222450376
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.150
- P53_PATHWAY+0.000
- ESTROGEN_RESPONSE_EARLY-0.010
- HEME_METABOLISM-0.020
- UV_RESPONSE_UP-0.030
- DNA_REPAIR-0.040
- XENOBIOTIC_METABOLISM-0.050
- MITOTIC_SPINDLE-0.060
- WNT_BETA_CATENIN_SIGNALING-0.060
- BILE_ACID_METABOLISM-0.080
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.570
- ANGIOGENESIS-0.560
- MTORC1_SIGNALING-0.400
- ANDROGEN_RESPONSE-0.380
- E2F_TARGETS-0.370
- G2M_CHECKPOINT-0.350
- INFLAMMATORY_RESPONSE-0.350
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.350
- UV_RESPONSE_DN-0.330
- MYC_TARGETS_V1-0.310
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR23303775 | — | — | 0.899 |
| 2 | SRR650134 | — | — | 0.892 |
| 3 | R87 | — | — | 0.890 |
| 4 | 20050097.LumA | — | B | 0.888 |
| 5 | SRR1388504 | GTEX | — | 0.880 |
| 6 | MNG1271 | — | — | 0.877 |
| 7 | MDT-AP-0394 | Med | Medulloblastoma | 0.875 |
| 8 | SRR1377984 | GTEX | — | 0.868 |
| 9 | MDT-AP-1160 | Med | Medulloblastoma | 0.866 |
| 10 | ULC0589T_S77 | — | cohortA1 | 0.866 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 1 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.150 | Remibrutinib | — uncovered |