TCGA-LQ-A4E4-01A-11R-A266-07
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
- overall_survival_months
- 28
- os_event
- false
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.170
- E2F_TARGETS+0.130
- MYC_TARGETS_V2+0.120
- MITOTIC_SPINDLE+0.060
- DNA_REPAIR+0.030
- FATTY_ACID_METABOLISM+0.000
- PEROXISOME-0.010
- ADIPOGENESIS-0.020
- SPERMATOGENESIS-0.020
- ESTROGEN_RESPONSE_LATE-0.040
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.580
- INTERFERON_GAMMA_RESPONSE-0.580
- TNFA_SIGNALING_VIA_NFKB-0.580
- INTERFERON_ALPHA_RESPONSE-0.520
- INFLAMMATORY_RESPONSE-0.510
- IL6_JAK_STAT3_SIGNALING-0.490
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.460
- APOPTOSIS-0.410
- COMPLEMENT-0.410
- IL2_STAT5_SIGNALING-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1385036 | GTEX | — | 0.929 |
| 2 | BS_A87NPZAP | medulloblastoma | — | 0.926 |
| 3 | SRR8518343 | — | E | 0.919 |
| 4 | SRR1441224 | GTEX | — | 0.919 |
| 5 | BS_D0RDN4K5 | Embryonal tumors | — | 0.918 |
| 6 | SRR1357413 | GTEX | — | 0.917 |
| 7 | SRR1399904 | GTEX | — | 0.916 |
| 8 | SRR807657 | GTEX | — | 0.916 |
| 9 | SRR1472621 | GTEX | — | 0.915 |
| 10 | SRR8518194 | — | D | 0.915 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.170 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.130 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.120 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.060 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.030 | Idelalisib | — uncovered |