MNG904
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.209
- APICAL_JUNCTION+0.169
- INTERFERON_GAMMA_RESPONSE+0.147
- HEDGEHOG_SIGNALING+0.120
- APICAL_SURFACE+0.115
- MITOTIC_SPINDLE+0.105
- PEROXISOME+0.099
- KRAS_SIGNALING_UP+0.050
- MYOGENESIS+0.042
- ALLOGRAFT_REJECTION+0.035
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.569
- MYC_TARGETS_V1-0.497
- CHOLESTEROL_HOMEOSTASIS-0.472
- MYC_TARGETS_V2-0.472
- TNFA_SIGNALING_VIA_NFKB-0.389
- E2F_TARGETS-0.342
- G2M_CHECKPOINT-0.333
- MTORC1_SIGNALING-0.326
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.294
- TGF_BETA_SIGNALING-0.284
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-55-A48X-01A-11R-A24H-07 | — | cohortA1 | 0.869 |
| 2 | X65f5effa.07f7.4ed3.9e0a.3a0d9d451474 | — | cohortA1 | 0.859 |
| 3 | 88448 | EPN | Supratentorial EPN | 0.848 |
| 4 | TCGA-NJ-A55A-01A-11R-A262-07 | — | cohortA1 | 0.842 |
| 5 | SRR8526730 | — | cohortA1 | 0.841 |
| 6 | MNG961 | — | — | 0.835 |
| 7 | BS_4W68NV3M | Med | Medulloblastoma | 0.819 |
| 8 | s0122234 | — | — | 0.818 |
| 9 | SRR1382732 | GTEX | — | 0.810 |
| 10 | ERR2208971 | — | — | 0.808 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.209 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.169 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.147 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.120 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.115 | Temsirolimus | — uncovered |
| MITOTIC_SPINDLE | 0.105 | Inavolisib | — uncovered |
| PEROXISOME | 0.099 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.050 | Inavolisib | — uncovered |
| MYOGENESIS | 0.042 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.035 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.031 | Inavolisib | — uncovered |