23ff8bad-515b-4a23-a1b7-8596cb566522
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
- —
- age_years
- 76.2518822724162
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.200
- IL6_JAK_STAT3_SIGNALING+0.140
- INFLAMMATORY_RESPONSE+0.130
- PANCREAS_BETA_CELLS+0.070
- KRAS_SIGNALING_DN+0.020
- MITOTIC_SPINDLE+0.000
- SPERMATOGENESIS-0.030
- APICAL_SURFACE-0.040
- UV_RESPONSE_DN-0.040
- HEME_METABOLISM-0.050
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.540
- MYC_TARGETS_V2-0.440
- MYC_TARGETS_V1-0.410
- INTERFERON_ALPHA_RESPONSE-0.360
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.360
- MTORC1_SIGNALING-0.340
- GLYCOLYSIS-0.280
- INTERFERON_GAMMA_RESPONSE-0.280
- P53_PATHWAY-0.280
- E2F_TARGETS-0.270
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | AUR-AERW-TTP1-B-1-0-R-A741-41 | — | D | 0.881 |
| 2 | d1447a31-64bb-4e70-ae50-eeff7a605f38 | — | — | 0.880 |
| 3 | b8135e73-31c3-49af-b4da-a7ed5f28d68a | — | — | 0.877 |
| 4 | SRR627462 | GTEX | — | 0.875 |
| 5 | SRR627429 | GTEX | — | 0.870 |
| 6 | TCGA-A7-A0DB-01C-02R-A277-07 | — | D | 0.868 |
| 7 | 62454053-936d-4f19-8522-6219c47bdd1c | — | — | 0.862 |
| 8 | SRR627455 | GTEX | — | 0.858 |
| 9 | TCGA-AC-A3OD-01A-11R-A21T-07 | — | D | 0.854 |
| 10 | SRR627449 | GTEX | — | 0.848 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.200 | Remibrutinib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.140 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.130 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.070 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.020 | Remibrutinib | — uncovered |