Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0· v2
Ependymoma Hub
V1V2
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Kinase catalog

384 kinases · 37 high-confidence, 48 medium
ReferenceDerived
Showing 384 of 384
SymbolConfidenceSubstrateRBC name
ABL1—Abltide ABL1
ABL2—Abltide ABL2/ARG
ACVR1—Casein + MnALK2/ACVR1
ACVR1B—Casein + MnALK4/ACVR1B
ACVRL1—Casein + MnALK1/ACVRL1
ADRBK1—CaseinGRK2
ADRBK2—CaseinGRK3
AKT1—CrosstideAKT1
AKT2—CrosstideAKT2
AKT3—CrosstideAKT3
ALK—pEY ALK
ARAF—MEK1 (K97R)ARAF
AURKA—KemptideAurora A
AURKB—KemptideAurora B
AURKC—KemptideAurora C
AXLhighpEYAXL
BLK—pEYBLK
BMPR1A—Casein + MnALK3/BMPR1A
BMPR1B—Casein + MnALK6/BMPR1B
BMPR2—MBPBMPR2
BMX—pEYBMX/ETK
BRAF—MEK1 (K97R)BRAF
BRSK1—CHKtideBRSK1
BRSK2—ZIPtideBRSK2
BTK—pEYBTK
CAMK1—Autocamtide 2 + Ca-CaMCAMK1a
CAMK1D—Autocamtide 2 + Ca-CaMCAMK1d
CAMK1G—Autocamtide 2 + Ca-CaMCAMK1g
CAMK2AhighAutocamtide 2 + Ca-CaMCAMK2a
CAMK2BmediumAutocamtide 2 + Ca-CaMCAMK2b
CAMK2DhighZIPtide + Ca-CaM*CAMK2d
CAMK2G—ZIPtide + Ca-CaM*CAMK2g
CAMK4—ZIPtide + Ca-CaM*CAMK4
CAMKK1—MBP + Ca-CaMCAMKK1
CAMKK2mediumMBP + Ca-CaMCAMKK2
CDC42BPA—Long S6 Kinase substrate peptideMRCKa/CDC42BPA
CDC42BPB—Long S6 Kinase substrate peptideMRCKb/CDC42BPB
CDC42BPG—DAPK1tideDMPK2/CDC42BPG
CDC7/DBF4—PDKtideCDC7/DBF4
CDK1/CCNA2—RB ProteinCDK1/cyclin A
CDK1/CCNB1—RB ProteinCDK1/cyclin B
CDK1/CCNE1—RB ProteinCDK1/cyclin E
CDK11B/CCNK—SUPT5H+MnCDK11B/cyclin K
CDK12/CCNK—Pol2-CTDCDK12/cyclin K
CDK13/CCNK—Pol2-CTDCDK13/cyclin K
CDK14/CCNY—RB ProteinCDK14 (PFTK1)/cyclin Y
CDK15/CCNA2—RB ProteinCDK15/cyclin A2
CDK15/CCNB1—RB Protein + MnCDK15/cyclin B1
CDK16/CCNY—RB ProteinCDK16/cyclin Y
CDK17/CCNY—MBPCDK17/cyclin Y (PCTK2)
CDK18/CCNY—RB ProteinCDK18/cyclin Y
CDK19/CCNC—Pol2-CTDCDK19/cyclin C
CDK2/CCNA1—RB ProteinCDK2/cyclin A1
CDK2/CCNA2—RB ProteinCDK2/cyclin A
CDK2/CCNE1—RB ProteinCDK2/cyclin E
CDK2/CCNE2—RB ProteinCDK2/cyclin E2
CDK2/CCNO—Histone H1CDK2/cyclin O
CDK3/CCNC—CHKtideCDK3/cyclin C
CDK3/CCNE1—RB ProteinCDK3/cyclin E
CDK3/CCNE2—RB ProteinCDK3/cyclin E2
CDK4/CCND1—RB ProteinCDK4/cyclin D1
CDK4/CCND2—RB ProteinCDK4/cyclin D2
CDK4/CCND3—RB ProteinCDK4/cyclin D3
CDK5/CDK5R1—RB ProteinCDK5/p25
CDK6/CCND1—RB ProteinCDK6/cyclin D1
CDK6/CCND2—RB ProteinCDK6/cyclin D2
CDK6/CCND3—RB ProteinCDK6/cyclin D3
CDK7/CCNH/MNAT1—Pol2-CTDCDK7/cyclin H
CDK8/CCNC—Pol2-CTDCDK8/cyclin C
CDK9/CCNK—Pol2-CTDCDK9/cyclin K
CDK9/CCNT1—Pol2-CTDCDK9/cyclin T1
CDK9/CCNT2—Pol2-CTDCDK9/cyclin T2
CHEK1—CHKtideCHK1
CHEK2—CHKtideCHK2
CHUK—IKKtideIKKa/CHUK
CIT—DAPK1STK21/CIT
CLK1highMBPCLK1
CLK2mediumMBPCLK2
CLK3—MBPCLK3
CLK4mediumMBPCLK4
CSF1R—pEY + MnFMS
CSK—pEYCSK
CSNK1A1—CK1tideCK1a1
CSNK1A1L—CK1tideCK1a1L
CSNK1D—CK1tideCK1d
CSNK1E—CK1tideCK1epsilon
CSNK1G1—CK1tideCK1g1
CSNK1G2—CK1tideCK1g2
CSNK1G3—CK1tideCK1g3
CSNK2A1—CK2 subCK2a
CSNK2A2—CK2 subCK2a2
DAPK1mediumZIPtideDAPK1
DAPK2mediumZIPtide + Ca-CaMDAPK2
DAPK3—ZIPtideZIPK/DAPK3
DCLK1—ZIPtideDCAMKL1
DCLK2—ZIPtideDCAMKL2
DCLK3—ZiptideDCAMKL3
DDR1highIRS1tideDDR1
DDR2highAXLtide + MnDDR2
DMPK—SGKtideDMPK
DSTYK—MBPRIPK5
DYRK1AmediumDYRKtideDYRK1/DYRK1A
DYRK1BmediumDYRKtideDYRK1B
DYRK2mediumDYRKtideDYRK2
DYRK3mediumDYRKtideDYRK3
DYRK4—DYRKtideDYRK4
EGFR—pEY + MnEGFR
EPHA1highpEY + MnEPHA1
EPHA2highpEYEPHA2
EPHA3highpEY + MnEPHA3
EPHA4highpEY + MnEPHA4
EPHA5highpEY + MnEPHA5
EPHA6highpEY + MnEPHA6
EPHA7mediumpEYEPHA7
EPHA8mediumpEYEPHA8
EPHB1highpEYEPHB1
EPHB2highpEY + MnEPHB2
EPHB3highpEYEPHB3
EPHB4highpEYEPHB4
ERBB2—pEY + MnERBB2/HER2
ERBB4—pEY + MnERBB4/HER4
ERN1mediumMBPERN1/IRE1
ERN2—MBPERN2/IRE2
FERhighpEYFER
FES—pEYFES/FPS
FGFR1—pEY + MnFGFR1
FGFR2—pEY + MnFGFR2
FGFR3—pEY + MnFGFR3
FGFR4—pEY + MnFGFR4
FGR—pEYFGR
FLT1—pEY + MnFLT1/VEGFR1
FLT3—AbltideFLT3
FLT4—pEY + MnFLT4/VEGFR3
FRK—pEY + MnFRK/PTK5
FYN—pEYFYN
GRK1—CaseinGRK1
GRK4—CaseinGRK4
GRK5—CaseinGRK5
GRK6—CaseinGRK6
GRK7highCaseinGRK7
GSG2—Histone H3Haspin
GSK3AmediumPhospho-Glycogen Synthase peptideGSK3a
GSK3BhighPhospho-Glycogen Synthase peptideGSK3b
HCK—Src Substrate peptideHCK
HIPK1—MBPHIPK1
HIPK2mediumMBPHIPK2
HIPK3—MBPHIPK3
HIPK4highMBPHIPK4
ICKmediumMBP + MnLCK2/ICK
IGF1R—pEY + MnIGF1R
IKBKB—IKKtideIKKb/IKBKB
IKBKE—CaseinIKKe/IKBKE
INSR—pEY + MnIR
INSRR—AXLtideIRR/INSRR
IRAK1highMBPIRAK1
IRAK2—Modified AKTIRAK2
IRAK4mediumMBPIRAK4
ITK—MBPITK
JAK1—pEYJAK1
JAK2—pEYJAK2
JAK3—JAK3tideJAK3
KDR—pEY + MnKDR/VEGFR2
KIT—pEYc-Kit
LATS1mediumSGKtideLATS1
LATS2mediumSGKtideLATS2
LCK—pEY + MnLCK
LIMK1highCofilin 1LIMK1
LIMK2highCofilin 2 + MnLIMK2
LRRK2highLRRKtideLRRK2
LTK—ABLtideTYK1/LTK
LYNmediumpEYLYN
MAKmediumMBPMAK
MAP2K1—ERK(K52R)MEK1
MAP2K2—ERK(K52R) MEK2
MAP2K4—JNK(K55M)MKK4
MAP2K5—ERK5 (K84R)MEK5
MAP2K6—p38a (K53A)MKK6
MAP2K7—JNK (K55M)MKK7
MAP3K1—MBPMEKK1
MAP3K10—MBPMLK2/MAP3K10
MAP3K11—MBPMLK3/MAP3K11
MAP3K12—MBPDLK/MAP3K12
MAP3K14—MBPNIK/MAP3K14
MAP3K19highMBPYSK4/MAP3K19
MAP3K2—MBPMEKK2
MAP3K3—MBPMEKK3
MAP3K5—MBPASK1/MAP3K5
MAP3K6—MBPMEKK6
MAP3K7/MAP3K7IP1—CaseinTAK1
MAP3K8—MEK1 (K97R)COT1/MAP3K8
MAP3K9—CaseinMLK1/MAP3K9
MAP4K1—MBPHPK1/MAP4K1
MAP4K2—MBPGCK/MAP4K2
MAP4K3—MBPGLK/MAP4K3
MAP4K4—MBPHGK/MAP4K4
MAP4K5—MBPKHS/MAP4K5
MAPK1—MBPERK2/MAPK1
MAPK10—ATF2JNK3
MAPK11—MBPP38b/MAPK11
MAPK12—MBPP38g/MAPK12
MAPK13—MBPP38d/MAPK13
MAPK14—MBPP38a/MAPK14
MAPK15—MBPERK7/MAPK15
MAPK3—MBPERK1/MAPK3
MAPK7—MBPERK5/MAPK7
MAPK8—ATF2JNK1
MAPK9—ATF2JNK2
MAPKAPK2—Glycogen Synthase-derived peptideMAPKAPK2
MAPKAPK3—Glycogen Synthase-derived peptideMAPKAPK3
MAPKAPK5—Glycogen Synthase-derived peptideMAPKAPK5/PRAK
MARK1—CHKtideMARK1
MARK2—CHKtideMARK2/PAR-1Ba
MARK3—CHKtideMARK3
MARK4—CHKtideMARK4
MAST3—ARPP19 + MnMAST3
MASTL—ARPP19MASTL
MATK—pEYCTK/MATK
MELKmediumZIPtideMELK
MERTK—pEYc-MER
MET—pEYc-MET
MINK1—MBPMINK/MINK1
MKNK1—MBPMNK1
MKNK2—MBPMNK2
MP2K3—p38a (K53A)MEK3
MST1R—Axltide + MnRON/MST1R
MST4mediumMBPMST4
MUSKhighMBP + MnMUSK
MYLK—ZIPtide + Ca-CaMMLCK/MYLK
MYLK2—ZIPtide + Ca-CaMMLCK2/MYLK2
MYLK3—DAPK1tide + Ca-CaMMYLK3
MYLK4mediumDAPKtideMYLK4
MYO3A—MBPMYO3A
MYO3BhighMBPMYO3B
NEK1—MBPNEK1
NEK11mediumMBPNEK11
NEK2mediumMBPNEK2
NEK3—MBPNEK3
NEK4mediumMBPNEK4
NEK5mediumMBPNEK5
NEK6—CaseinNEK6
NEK7—CaseinNEK7
NEK8—MBPNEK8
NEK9highMBPNEK9
NIM1—CHKtide NIM1
NLK—MBPNLK
NTRK1—pEY + Mn TRKA
NTRK2—pEY + Mn TRKB
NTRK3—pEYTRKC
NUAK1—CHKtideARK5/NUAK1
NUAK2—CHKtideSNARK/NUAK2
OXSR1—CATCHtideOSR1/OXSR1
PAK1—PAKtidePAK1
PAK2—PAKtidePAK2
PAK3—PAKtidePAK3
PAK4—PAKtidePAK4
PAK6—PAKtidePAK6
PAK7—PAKtidePAK5
PASK—ZIPtidePASK
PBK—MBPPBK/TOPK
PDGFRA—pEY + MnPDGFRa
PDGFRB—pEY + MnPDGFRb
PDPK1—PDKtidePDK1/PDPK1
PEAK1highpEYPEAK1
PHKG1mediumZIPtidePHKg1
PHKG2mediumZIPtidePHKg2
PIM1mediumPim2tidePIM1
PIM2—Pim2tidePIM2
PIM3mediumPim2tidePIM3
PKMYT1—MBPPKMYT1
PKN1mediumGlycogen Synthase-derived peptidePKN1/PRK1
PKN2mediumGlycogen Synthase-derived peptidePKN2/PRK2
PKN3mediumSGKtidePKN3/PRK3
PLK1—CaseinPLK1
PLK2—CaseinPLK2
PLK3—CaseinPLK3
PLK4mediumCaseinPLK4/SAK
PNCK—Autocamtide 2 + Ca-CaMCAMK1b
PRKACA—PKA subPKA
PRKACB—Long S6 Kinase substrate peptidePKAcb
PRKACG—Long S6 Kinase substrate peptidePKAcg
PRKCA—PKCe Peptide + Lipid ActivatorPKCa
PRKCB1—PKCe Pep + Lipid ActivatorPKCb1
PRKCB2—PKCe Pep + Lipid ActivatorPKCb2
PRKCD—PKCe Pep + Lipid ActivatorPKCd
PRKCE—PKCe Pep + Lipid ActivatorPKCepsilon
PRKCG—PKCe peptide + Lipid ActivatorPKCg
PRKCH—PKCe Pep + Lipid ActivatorPKCeta
PRKCI—PKCepsilon PeptidePKCiota
PRKCQ—PKCe Pep + Lipid ActivatorPKCtheta
PRKCZ—PKCepsilon PeptidePKCzeta
PRKD1—Glycogen Synthase-derived peptidePKCmu/PRKD1
PRKD2—Glycogen Synthase-derived peptidePKD2/PRKD2
PRKD3—Glycogen Synthase-derived peptidePKCnu/PRKD3
PRKG1—KemptidePKG1a
PRKG2—KemptidePKG2/PRKG2
PRKXhighKemptidePRKX
PTK2—pEYFAK/PTK2
PTK2B—pEY + MnPYK2
PTK6—pEY + MnBRK
RAF1—MEK1 (K97R) RAF1
RET—TRK-C derived peptideRET
RIPK2mediumMBPRIPK2
RIPK3highMBPRIPK3
RIPK4—Histone H2ARIPK4
ROCK1—Long S6 Kinase substrate peptideROCK1
ROCK2—Long S6 Kinase substrate peptideROCK2
ROS1—IGF-1RtideROS/ROS1
RPS6KA1—Glycogen Synthase-derived peptideRSK1
RPS6KA2—Glycogen Synthase-derived peptideRSK3
RPS6KA3—Glycogen Synthase-derived peptideRSK2
RPS6KA4—CrosstideMSK2/RPS6KA4
RPS6KA5—CrosstideMSK1/RPS6KA5
RPS6KA6—Long S6 Kinase substrate peptideRSK4
RPS6KB1—S6K/Rsk2 peptide 2p70S6K/RPS6KB1
RPS6KB2—S6K/Rsk2 peptide 2p70S6Kb/RPS6KB2
SBK1—PKA subSBK1
SGK1—CrosstideSGK1
SGK2—CrosstideSGK2
SGK3—CrosstideSGK3/SGKL
SIK1mediumAMARA peptideSIK1
SIK2—AMARA peptideSIK2
SIK3mediumAMARA peptideSIK3
SLKmediumHistone H3SLK/STK2
SNRK—MBPSNRK
SRC—pEYc-Src
SRMSmediumpEY + MnSRMS
SRPK1highRS peptideSRPK1
SRPK2mediumRS peptideSRPK2
SRPK3—RS peptideMSSK1/STK23
STK10—LRRKtideLOK/STK10
STK11/STRADA/CAB39—LKB1tideLKB1
STK16mediumMBPSTK16
STK17A—ZIPtideDRAK1/STK17A
STK24—MBPMST3/STK24
STK25highMBPSTK25/YSK1
STK3—MBPMST2/STK3
STK32A—Casein + MnSTK32A/YANK1
STK32BmediumMBP + MnSTK32B/YANK2
STK32C—MBP + MnSTK32C/YANK3
STK33—MBPSTK33
STK35—RS Peptide Long + MnSTK35/CLIK1
STK38-MOBKL1A—SGKtideSTK38/NDR1
STK38L-MOBKL1A—SGKtideSTK38L/NDR2
STK39—MBPSTK39/STLK3
STK4—AxltideMST1/STK4
SYK—pEYSYK
TAOK1—MBPTAOK1
TAOK2highMBPTAOK2
TAOK3—MBPTAOK3/JIK
TBK1—MBPTBK1
TEC—pEY + Mn TEC
TEK—pEY + Mn TIE2/TEK
TESK1mediumCofilin 2 + MnTESK1
TESK2mediumCofilin 2TESK2
TGFBR1—Casein + MnALK5/TGFBR1
TGFBR2—MBPTGFBR2
TLK1—Histone H3TLK1
TLK2—CaseinTLK2
TNIKhighLRRKtideTNIK
TNK1highpEY + Mn TNK1
TNK2—Lyntide 2+MnACK1
TSSK1B—CHKtideSTK22D/TSSK1
TSSK2—CHKtideTSSK2
TSSK3—CHKtideTSSK3/STK22C
TSSK4—RS Peptide Long + MnTSSK4
TSSK6—MBPSSTK/TSSK6
TTBK1—MBPTTBK1
TTBK2—MBPTTBK2
TTK—MBP + MnTTK
TXK—ABLtideTXK
TYK2—AXLtide TYK2
TYRO3mediumpEY + Mn TYRO3/SKY
ULK1—MBPULK1
ULK2mediumMBPULK2
ULK3—CaseinULK3
VRK1—Long S6 Kinase substrate peptideVRK1
VRK2—Casein + MnVRK2
WEE1—CDK1 (D146N)/cyclin B1WEE1
WNK1—MBPWNK1
WNK2—MBPWNK2
WNK3—MBPWNK3
YES1—pEYYES/YES1
ZAKhighMBPZAK/MLTK
ZAP70—pEYZAP70