UniProt P10398 · PDB · AlphaFold · Substrate: MEK1 (K97R) · Clone: aa 282-end
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ripretinib | 100.0% | 0.0% | 92.95 | 0.674 |
| 2 | Sorafenib | 100.0% | 0.0% | 96.72 | 0.776 |
| 3 | Ponatinib | 99.0% | 1.0% | 78.23 | 0.534 |
| 4 | Regorafenib | 98.8% | 1.2% | 95.99 | 0.719 |
| 5 | Encorafenib | 97.4% | 2.6% | 98.50 | 0.755 |
| 6 | Vemurafenib | 96.9% | 3.1% | 96.49 | 0.598 |
| 7 | Dabrafenib | 96.3% | 3.7% | 94.74 | 0.633 |
| 8 | Apatinib | 90.7% | 9.3% | 97.73 | 0.704 |
| 9 | Dasatinib | 86.2% | 13.8% | 87.97 | 0.699 |
| 10 | Umbralisib | 84.9% | 15.1% | 98.74 | 0.670 |
| 11 | Ibrutinib | 84.8% | 15.2% | 94.74 | 0.723 |
| 12 | Nilotinib | 81.8% | 18.2% | 96.49 | 0.765 |
| 13 | Upadacitinib | 64.9% | 35.1% | 97.98 | 0.663 |
| 14 | Dacomitinib | 61.5% | 38.5% | 97.99 | 0.664 |
| 15 | Acalabrutinib | 58.3% | 41.7% | 99.50 | 0.670 |
| 16 | Pazopanib | 51.1% | 48.9% | 97.49 | 0.672 |
| 17 | Lapatinib | 47.3% | 52.7% | 99.25 | 0.616 |
| 18 | Pacritinib | 46.9% | 53.1% | 88.64 | 0.452 |
| 19 | Abemaciclib | 44.2% | 55.8% | 91.48 | 0.563 |
| 20 | Erdafitinib | 43.9% | 56.1% | 95.71 | 0.737 |
Paralog block
ARAF, BRAF, RAF1
EMT expression
- Mesenchymal log2(TPM+1): 5.24
- Epithelial log2(TPM+1): 4.87
- Fold change: 0.36
- Status: No significant change
Selectivity landscape vs inhibition on ARAF
Each point is one of the 92 approved drugs; color = inhibition % on ARAF.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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