PDGFRB(PDGFRb)
Sign in to save this workspaceUniProt P09619 · PDB · AlphaFold · Substrate: pEY + Mn · Clone: Cytoplasmic (558-1106)
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ponatinib | 100.0% | 0.0% | 78.23 | 0.534 |
| 2 | Nintedanib | 96.0% | 4.0% | 90.23 | 0.608 |
| 3 | Tivozanib | 95.8% | 4.2% | 92.42 | 0.673 |
| 4 | Regorafenib | 95.4% | 4.6% | 95.99 | 0.719 |
| 5 | Axitinib | 92.9% | 7.1% | 93.23 | 0.688 |
| 6 | Dasatinib | 92.5% | 7.5% | 87.97 | 0.699 |
| 7 | Avapritinib | 90.4% | 9.6% | 97.73 | 0.644 |
| 8 | Midostaurin | 89.9% | 10.1% | 78.64 | 0.500 |
| 9 | Ripretinib | 89.1% | 10.9% | 92.95 | 0.674 |
| 10 | Quizartinib | 89.0% | 11.0% | 99.50 | 0.737 |
| 11 | Nilotinib | 86.7% | 13.3% | 96.49 | 0.765 |
| 12 | Sunitinib | 84.8% | 15.2% | 91.73 | 0.524 |
| 13 | Pralsetinib | 81.3% | 18.7% | 93.43 | 0.643 |
| 14 | Apatinib | 80.9% | 19.1% | 97.73 | 0.704 |
| 15 | Sorafenib | 80.8% | 19.1% | 96.72 | 0.776 |
| 16 | Selpercatinib | 80.3% | 19.7% | 96.72 | 0.635 |
| 17 | Erdafitinib | 78.8% | 21.2% | 95.71 | 0.737 |
| 18 | Pazopanib | 75.1% | 24.9% | 97.49 | 0.672 |
| 19 | Pacritinib | 72.7% | 27.3% | 88.64 | 0.452 |
| 20 | Imatinib | 70.7% | 29.3% | 99.00 | 0.718 |
Paralog block
PDGFRA, PDGFRB
EMT expression
- Mesenchymal log2(TPM+1): 4.46
- Epithelial log2(TPM+1): 0.53
- Fold change: 3.93
- Status: Upregulated
Selectivity landscape vs inhibition on PDGFRB
Each point is one of the 92 approved drugs; color = inhibition % on PDGFRB.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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