SRR1339218
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.346
- SPERMATOGENESIS+0.211
- MYOGENESIS+0.210
- KRAS_SIGNALING_DN+0.191
- HEDGEHOG_SIGNALING+0.183
- UV_RESPONSE_DN+0.077
- FATTY_ACID_METABOLISM+0.074
- ADIPOGENESIS+0.061
- APICAL_JUNCTION+0.021
- HEME_METABOLISM+0.021
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.517
- TNFA_SIGNALING_VIA_NFKB-0.481
- INTERFERON_GAMMA_RESPONSE-0.474
- IL6_JAK_STAT3_SIGNALING-0.465
- E2F_TARGETS-0.421
- ALLOGRAFT_REJECTION-0.417
- INFLAMMATORY_RESPONSE-0.415
- G2M_CHECKPOINT-0.407
- CHOLESTEROL_HOMEOSTASIS-0.401
- MYC_TARGETS_V1-0.359
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1478077 | GTEX | — | 0.964 |
| 2 | SRR1322555 | GTEX | — | 0.962 |
| 3 | SRR598253 | GTEX | — | 0.958 |
| 4 | SRR1329377 | GTEX | — | 0.956 |
| 5 | SRR657348 | GTEX | — | 0.955 |
| 6 | SRR1474065 | GTEX | — | 0.954 |
| 7 | SRR1353157 | GTEX | — | 0.952 |
| 8 | SRR1359388 | GTEX | — | 0.950 |
| 9 | SRR598428 | GTEX | — | 0.950 |
| 10 | SRR1465356 | GTEX | — | 0.950 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.346 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.211 | Inavolisib | — uncovered |
| MYOGENESIS | 0.210 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.191 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.183 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.077 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.074 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.061 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.021 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.021 | Temsirolimus | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.021 | Inavolisib | — uncovered |