Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-P3-A6T4-01A-11R-A34R-07

44c6cd67-f406-5ff5-8d8b-8802d4a956ae

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0.014155251
sex
male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PANCREAS_BETA_CELLS+0.380
  • PROTEIN_SECRETION+0.200
  • MYC_TARGETS_V2+0.110
  • UV_RESPONSE_UP+0.100
  • BILE_ACID_METABOLISM+0.090
  • TNFA_SIGNALING_VIA_NFKB+0.070
  • XENOBIOTIC_METABOLISM+0.050
  • SPERMATOGENESIS+0.030
  • NOTCH_SIGNALING+0.020
  • HEME_METABOLISM+0.010

Top 10 suppressed

  • E2F_TARGETS-0.550
  • HEDGEHOG_SIGNALING-0.460
  • G2M_CHECKPOINT-0.430
  • ALLOGRAFT_REJECTION-0.390
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.370
  • IL2_STAT5_SIGNALING-0.360
  • ANGIOGENESIS-0.350
  • APICAL_JUNCTION-0.340
  • MYOGENESIS-0.340
  • UV_RESPONSE_DN-0.340

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR2016961
head-neck@1
0.817
2TCGA-CF-A5U8-01A-11R-A28M-07
bladder-landscape@3
0.785
3TCGA-GC-A3RD-01A-12R-A22U-07
bladder-landscape@3
0.772
4SRR8943008
bladder-landscape@3
0.769
5TCGA-55-6972-01A-11R-1949-07
lung-landscapes@6
cohortA20.767
6TCGA-CF-A27C-01A-11R-A16R-07
bladder-landscape@3
0.765
71d0437fc-c8ad-47be-822d-b95ad10f0e4a
colon-landscapes@1
0.763
8AUR-AEPZ-TTM1-A-1-1-R-A742-41
breast-umap@18
B0.761
9R58
bladder-landscape@3
0.759
10MDT-AP-2993
medullo-epn-umap@date-based
MedMedulloblastoma0.757

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 11 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.380Cobimetinib— uncovered
PROTEIN_SECRETION0.200Remibrutinib— uncovered
MYC_TARGETS_V20.110Idelalisib— uncovered
UV_RESPONSE_UP0.100Idelalisib— uncovered
BILE_ACID_METABOLISM0.090Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.070Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.050Inavolisib— uncovered
SPERMATOGENESIS0.030Inavolisib— uncovered
NOTCH_SIGNALING0.020Inavolisib— uncovered
HEME_METABOLISM0.010Temsirolimus— uncovered
UNFOLDED_PROTEIN_RESPONSE0.010Idelalisib— uncovered