SRR1320873
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.389
- KRAS_SIGNALING_DN+0.216
- SPERMATOGENESIS+0.175
- PEROXISOME+0.141
- NOTCH_SIGNALING+0.121
- WNT_BETA_CATENIN_SIGNALING+0.112
- OXIDATIVE_PHOSPHORYLATION+0.097
- PANCREAS_BETA_CELLS+0.087
- PROTEIN_SECRETION+0.087
- FATTY_ACID_METABOLISM+0.079
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.515
- IL6_JAK_STAT3_SIGNALING-0.515
- G2M_CHECKPOINT-0.461
- E2F_TARGETS-0.458
- INFLAMMATORY_RESPONSE-0.454
- COMPLEMENT-0.443
- COAGULATION-0.394
- INTERFERON_GAMMA_RESPONSE-0.391
- ANGIOGENESIS-0.380
- INTERFERON_ALPHA_RESPONSE-0.368
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1329334 | GTEX | — | 0.904 |
| 2 | SRR600445 | GTEX | — | 0.903 |
| 3 | SRR1375308 | GTEX | — | 0.898 |
| 4 | SRR1440986 | GTEX | — | 0.893 |
| 5 | SRR1072504 | GTEX | — | 0.892 |
| 6 | SRR1465356 | GTEX | — | 0.887 |
| 7 | SRR1435536 | GTEX | — | 0.883 |
| 8 | SRR1322555 | GTEX | — | 0.881 |
| 9 | SRR1446092 | GTEX | — | 0.880 |
| 10 | SRR1356036 | GTEX | — | 0.875 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.389 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.216 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.175 | Inavolisib | — uncovered |
| PEROXISOME | 0.141 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.121 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.112 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.097 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.087 | Cobimetinib | — uncovered |
| PROTEIN_SECRETION | 0.087 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.079 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.063 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.039 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.017 | Remibrutinib | — uncovered |
| UV_RESPONSE_UP | 0.006 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.001 | Idelalisib | — uncovered |