SRR1375308
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.302
- HEDGEHOG_SIGNALING+0.278
- SPERMATOGENESIS+0.247
- OXIDATIVE_PHOSPHORYLATION+0.226
- PROTEIN_SECRETION+0.225
- PANCREAS_BETA_CELLS+0.121
- UV_RESPONSE_DN+0.120
- UV_RESPONSE_UP+0.094
- ESTROGEN_RESPONSE_EARLY+0.075
- MYOGENESIS+0.066
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.629
- INTERFERON_GAMMA_RESPONSE-0.552
- ALLOGRAFT_REJECTION-0.512
- IL6_JAK_STAT3_SIGNALING-0.509
- INFLAMMATORY_RESPONSE-0.481
- E2F_TARGETS-0.451
- COAGULATION-0.413
- G2M_CHECKPOINT-0.388
- TNFA_SIGNALING_VIA_NFKB-0.358
- IL2_STAT5_SIGNALING-0.339
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR600445 | GTEX | — | 0.935 |
| 2 | SRR1390601 | GTEX | — | 0.920 |
| 3 | SRR1464373 | GTEX | — | 0.916 |
| 4 | SRR1487194 | GTEX | — | 0.909 |
| 5 | SRR1322555 | GTEX | — | 0.909 |
| 6 | SRR1459718 | GTEX | — | 0.908 |
| 7 | SRR1084842 | GTEX | — | 0.900 |
| 8 | SRR602704 | GTEX | — | 0.899 |
| 9 | SRR821626 | GTEX | — | 0.898 |
| 10 | SRR1320873 | GTEX | — | 0.898 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.302 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.278 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.247 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.226 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.225 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.121 | Cobimetinib | — uncovered |
| UV_RESPONSE_DN | 0.120 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.094 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.075 | Inavolisib | — uncovered |
| MYOGENESIS | 0.066 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.064 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.059 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.008 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.004 | Inavolisib | — uncovered |