SRR12475165
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.270
- MYC_TARGETS_V1+0.210
- UNFOLDED_PROTEIN_RESPONSE+0.100
- DNA_REPAIR+0.090
- PROTEIN_SECRETION+0.050
- FATTY_ACID_METABOLISM+0.020
- KRAS_SIGNALING_DN+0.000
- MYC_TARGETS_V2+0.000
- BILE_ACID_METABOLISM-0.030
- GLYCOLYSIS-0.050
Top 10 suppressed
- ANGIOGENESIS-0.620
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.570
- TGF_BETA_SIGNALING-0.430
- APICAL_SURFACE-0.400
- CHOLESTEROL_HOMEOSTASIS-0.380
- COAGULATION-0.370
- INTERFERON_ALPHA_RESPONSE-0.370
- NOTCH_SIGNALING-0.370
- APICAL_JUNCTION-0.360
- MYOGENESIS-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | R16 | — | — | 0.889 |
| 2 | SRR1429307 | GTEX | — | 0.884 |
| 3 | SRR1456841 | GTEX | — | 0.883 |
| 4 | SRR1385036 | GTEX | — | 0.880 |
| 5 | SRR1069188 | GTEX | — | 0.879 |
| 6 | 425dc52d-fb29-45d5-8d94-aab524136a83 | — | — | 0.879 |
| 7 | SRR1351325 | GTEX | — | 0.879 |
| 8 | SRR1499442 | GTEX | — | 0.878 |
| 9 | SRR1340420 | GTEX | — | 0.876 |
| 10 | SRR8518194 | — | D | 0.875 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.270 | Remibrutinib | — uncovered |
| MYC_TARGETS_V1 | 0.210 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.100 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.090 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.050 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.020 | Inavolisib | — uncovered |