Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-UL-AAZ6-01A-11R-A41B-07

· B

8e6eb74b-d4cf-5a60-a2ce-9c5318094844

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
17

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PANCREAS_BETA_CELLS+0.510
  • MYC_TARGETS_V2+0.360
  • INTERFERON_ALPHA_RESPONSE+0.310
  • KRAS_SIGNALING_DN+0.280
  • ESTROGEN_RESPONSE_LATE+0.250
  • OXIDATIVE_PHOSPHORYLATION+0.230
  • ESTROGEN_RESPONSE_EARLY+0.220
  • MYC_TARGETS_V1+0.180
  • GLYCOLYSIS+0.170
  • DNA_REPAIR+0.150

Top 10 suppressed

  • TGF_BETA_SIGNALING-0.470
  • UV_RESPONSE_DN-0.460
  • WNT_BETA_CATENIN_SIGNALING-0.440
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.420
  • MITOTIC_SPINDLE-0.380
  • ANDROGEN_RESPONSE-0.360
  • PROTEIN_SECRETION-0.360
  • ALLOGRAFT_REJECTION-0.310
  • NOTCH_SIGNALING-0.310
  • COMPLEMENT-0.260

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-GD-A6C6-01A-21R-A31N-07
bladder-landscape@3
0.813
2TCGA-94-7033-01A-11R-1949-07
lung-landscapes@6
cohortSQ10.797
3TCGA-GU-A763-01A-11R-A32O-07
bladder-landscape@3
0.786
4BS_TNRHHYNC
brain-umap@2
Spinal Cord Ependymoma0.778
5fa9f3cc6-06eb-4cfd-8f85-9d13df39d11e
melanoma-umap@29
0.777
6TCGA-OL-A66O-01A-11R-A31O-07
breast-umap@18
B0.766
7TCGA-AO-A03T-01A-21R-A034-07
breast-umap@18
B0.763
8TCGA-XF-AAN1-01A-31R-A42T-07
bladder-landscape@3
0.759
9SRR8518141
breast-umap@18
E0.758
1043c87798-5762-42c1-b7d8-47fc126fc2d3
melanoma-umap@29
0.754

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 20 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.510Cobimetinib— uncovered
MYC_TARGETS_V20.360Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.310Inavolisib— uncovered
KRAS_SIGNALING_DN0.280Remibrutinib— uncovered
ESTROGEN_RESPONSE_LATE0.250Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.230Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.220Inavolisib— uncovered
MYC_TARGETS_V10.180Inavolisib— uncovered
GLYCOLYSIS0.170Inavolisib— uncovered
DNA_REPAIR0.150Idelalisib— uncovered
MTORC1_SIGNALING0.130Inavolisib— uncovered
SPERMATOGENESIS0.110Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.100Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.080Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.070Idelalisib— uncovered
E2F_TARGETS0.060Inavolisib— uncovered
BILE_ACID_METABOLISM0.050Inavolisib— uncovered
PEROXISOME0.020Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.020Idelalisib— uncovered
UV_RESPONSE_UP0.010Idelalisib— uncovered