MNG842
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.286
- TGF_BETA_SIGNALING+0.263
- UV_RESPONSE_DN+0.260
- WNT_BETA_CATENIN_SIGNALING+0.249
- HEDGEHOG_SIGNALING+0.196
- PEROXISOME+0.175
- MITOTIC_SPINDLE+0.113
- INTERFERON_GAMMA_RESPONSE+0.110
- BILE_ACID_METABOLISM+0.089
- APICAL_SURFACE+0.075
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.361
- MTORC1_SIGNALING-0.351
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.333
- UV_RESPONSE_UP-0.319
- MYC_TARGETS_V2-0.278
- OXIDATIVE_PHOSPHORYLATION-0.278
- GLYCOLYSIS-0.277
- MYC_TARGETS_V1-0.273
- COMPLEMENT-0.263
- PI3K_AKT_MTOR_SIGNALING-0.251
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG320 | — | — | 0.821 |
| 2 | MBCproject_6016_T1_RNA | — | A | 0.773 |
| 3 | SRR8526730 | — | cohortA1 | 0.761 |
| 4 | aMVAC.P_002_TURBT_S219 | — | — | 0.747 |
| 5 | TCGA-A7-A26J-01B-02R-A277-07 | — | D | 0.739 |
| 6 | SRR33346954 | — | — | 0.738 |
| 7 | ULC1485T_S59 | — | cohortA1 | 0.733 |
| 8 | X21fbbe96.619e.4fba.9a39.8f9098cb173e | — | cohortA1 | 0.729 |
| 9 | MNG423 | — | — | 0.725 |
| 10 | R15 | — | — | 0.724 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.286 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.263 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.260 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.249 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.196 | Inavolisib | — uncovered |
| PEROXISOME | 0.175 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.113 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.110 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.089 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.075 | Temsirolimus | — uncovered |